The importance of coenzyme A (CoA) as a carrier of acyl residues in cell metabolism is well
understood. Coenzyme A participates in more than 100 different catabolic and anabolic …

Coenzyme A (CoA) is the predominant acyl carrier in mammalian cells and a cofactor that
plays a key role in energy and lipid metabolism. CoA and its thioesters (acyl-CoAs) regulate …

Covalent probes can display unmatched potency, selectivity, and duration of action;
however, their discovery is challenging. In principle, fragments that can irreversibly bind their …

Peroxisomes are membrane-bound organelles involved in many metabolic pathways and
essential for human health. They harbor a large number of enzymes involved in the different …

Pantothenate kinase (PANK) is a metabolic enzyme that regulates cellular coenzyme A
(CoA) levels. There are three human PANK genes, and inactivating mutations in PANK2 …

The tricarboxylic acid cycle, nutrient oxidation, histone acetylation and synthesis of lipids,
glycans and haem all require the cofactor coenzyme A (CoA). Although the sources and …

Proteins of the NUDIX hydrolase (NUDT) superfamily that cleave organic pyrophosphates
are found in all classes of organisms, from archaea and bacteria to higher eukaryotes. In …

It is a textbook definition that in the absence of oxygen or inhibition of the mitochondrial
respiratory chain by pharmacologic or genetic means, hyper-reduction of the matrix pyridine …

Animal models of psychopathologies are of exceptional interest for neurobiologists because
these models allow us to clarify molecular mechanisms underlying the pathologies. One …

Beta-oxidation (β-oxidation) is an important metabolic process involving multiple steps by
which fatty acid molecules are broken down to produce energy. The very long-chain fatty …