Mounting evidence implicates microRNAs (miRNAs) in the pathology of schizophrenia.
These small noncoding RNAs bind to mRNAs containing complementary sequences and …

Protein synthesis in eukaryotic cells is a complex, multi-step and tightly regulated process.
Translation initiation, the rate limiting step in protein synthesis, is dependent on the activity of …

Importance Biomarkers that are predictive of outcomes in individuals at risk of psychosis
would facilitate individualized prognosis and stratification strategies. Objective To …

Schizophrenia (SZ) is associated with dysfunction of the dorsolateral prefrontal cortex
(DLPFC). This dysfunction is manifest as cognitive deficits that appear to arise from …

AKT is a kinase regulating numerous cellular processes in the brain, and mutations in AKT
are known to affect brain function. AKT is indirectly implicated in synaptic plasticity, but its …

Abnormal neurotransmission is central to schizophrenia (SZ). Alterations across multiple
neurotransmitter systems in SZ suggest that this illness may be associated with …

Background Betaine is known to act against various biological stresses and its levels were
reported to be decreased in schizophrenia patients. We aimed to test the role of betaine in …

The AKT-mTOR signaling transduction pathway plays an important role in
neurodevelopment and synaptic plasticity. mTOR is a serine/threonine kinase that …

Background Though olfactory deficits are well-documented in schizophrenia, fewer studies
have examined olfactory performance profiles across the psychosis spectrum. The current …

The genetic and epigenetic factors contributing to risk for schizophrenia (SZ) remain
unresolved. Here we demonstrate, for the first time, perturbed global protein translation in …