▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

BACKGROUND Many clinicians and patients believe that endometriosis-associated pain is
due to the lesions. Yet causality remains an enigma, because pain symptoms attributed to …

The four mammalian neurotrophins—NGF, BDNF, NT-3 and NT-4—each bind and activate
one or more of the Trk family of receptor tyrosine kinases. Through these receptors …

The neurotrophin family of neurotrophic factors are well-known for their effects on neuronal
survival and growth. Over the past decade, considerable evidence has accumulated from …

Although skeletal pain plays a major role in reducing the quality of life in patients suffering
from osteoarthritis, Paget's disease, sickle cell anemia and bone cancer, little is known about …

Nerve growth factor (NGF) was originally discovered as a neurotrophic factor essential for
the survival of sensory and sympathetic neurons during development. However in the adult …

Wallerian degeneration (WD) is the inflammatory response of the nervous system to axonal
injury, primarily attributable to the production of cytokines, the mediator molecules of …

Wallerian degeneration is a cascade of stereotypical events in reaction to injury of nerve
fibres. These events consist of cellular and molecular alterations, including macrophage …

Disorders of the skeleton are one of the most common causes of chronic pain and long‐term
physical disability in the world. Chronic skeletal pain is caused by a remarkably diverse …