[HTML][HTML] From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections
M Chemudupati, AD Kenney, S Bonifati, A Zani… - … Et Biophysica Acta (BBA …, 2019 - Elsevier
Antiviral restriction factors are cellular proteins that inhibit the entry, replication, or spread of
viruses. These proteins are critical components of the innate immune system and function to …
viruses. These proteins are critical components of the innate immune system and function to …
SAMHD1 functions and human diseases
SAA Coggins, B Mahboubi, RF Schinazi, B Kim - Viruses, 2020 - mdpi.com
Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …
maintenance of genomic information in both cells and a variety of viral pathogens. While the …
TLR-3 stimulation skews M2 macrophages to M1 through IFN-αβ signaling and restricts tumor progression
A Vidyarthi, N Khan, T Agnihotri, S Negi… - Frontiers in …, 2018 - frontiersin.org
During tumor progression, macrophages shift their protective M1-phenotype to pro-
tumorigenic M2-subtype. Therefore, conversion of M2 to M1 phenotype may be a potential …
tumorigenic M2-subtype. Therefore, conversion of M2 to M1 phenotype may be a potential …
Characterisation of extracellular vesicle-subsets derived from brain endothelial cells and analysis of their protein cargo modulation after TNF exposure
V Dozio, JC Sanchez - Journal of extracellular vesicles, 2017 - Taylor & Francis
Little is known about the composition and functional differences between extracellular
vesicle (EV) subsets, such as microvesicles (MVs) and exosomes (EXOs), nor to what extent …
vesicle (EV) subsets, such as microvesicles (MVs) and exosomes (EXOs), nor to what extent …
SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a
deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the …
deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the …
Interferons induce expression of SAMHD1 in monocytes through down-regulation of miR-181a and miR-30a
M Riess, NV Fuchs, A Idica, M Hamdorf, E Flory… - Journal of Biological …, 2017 - ASBMB
SAMHD1 is a phosphohydrolase maintaining cellular dNTP homeostasis but also acts as a
critical regulator in innate immune responses due to its antiviral activity and association with …
critical regulator in innate immune responses due to its antiviral activity and association with …
SAMHD1 suppression of antiviral immune responses
SAMHD1 is a host triphosphohydrolase that degrades intracellular deoxynucleoside
triphosphates (dNTPs) to a lower level that restricts viral DNA synthesis, and thus prevents …
triphosphates (dNTPs) to a lower level that restricts viral DNA synthesis, and thus prevents …
Interplay between intrinsic and innate immunity during HIV infection
Restriction factors are antiviral components of intrinsic immunity which constitute a first line
of defense by blocking different steps of the human immunodeficiency virus (HIV) replication …
of defense by blocking different steps of the human immunodeficiency virus (HIV) replication …
SAMHD1 as the potential link between SARS-CoV-2 infection and neurological complications
The recent pandemic of coronavirus infectious illness 2019 (COVID19) triggered by SARS-
CoV-2 has rapidly spread around the globe, generating in severe events an acute, highly …
CoV-2 has rapidly spread around the globe, generating in severe events an acute, highly …
Virus-and interferon alpha-induced transcriptomes of cells from the microbat Myotis daubentonii
Antiviral interferons (IFN-alpha/beta) are possibly responsible for the high tolerance of bats
to zoonotic viruses. Previous studies focused on the IFN system of megabats (suborder …
to zoonotic viruses. Previous studies focused on the IFN system of megabats (suborder …