Polyploidy (or whole-genome duplication) is the condition of having more than two basic
sets of chromosomes. Polyploidization is well tolerated in many species and can lead to …

The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the
perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to …

Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

The identity of cellular populations that drive liver regeneration after injury is the subject of
intense study, and the contributions of polyploid hepatocytes to organ regeneration and …

Defining how organ size is regulated, a process controlled not only by the number of cells
but also by the size of the cells, is a frontier in developmental biology. Large cells are …

We present a unifying theory to explain cancer recurrence, therapeutic resistance, and
lethality. The basis of this theory is the formation of simultaneously polyploid and aneuploid …

Bursts of nascent mRNA have been shown to lead to substantial cell-cell variation in
unicellular organisms, facilitating diverse responses to environmental challenges. It is …

Polyploidization is one of the most dramatic changes that can occur in the genome. In the
liver, physiological polyploidization events occur during both liver development and …

A characteristic cellular feature of the mammalian liver is the progressive polyploidization of
the hepatocytes, where individual cells acquire more than two sets of chromosomes …

Centrosomes, the main microtubule-organizing centers in animal cells, are replicated
exactly once during the cell division cycle to form the poles of the mitotic spindle …