Depriving iron supply to the virus represents a promising adjuvant therapeutic against viral survival
W Liu, S Zhang, S Nekhai, S Liu - Current clinical microbiology reports, 2020 - Springer
Purpose of the review The ongoing outbreak of novel coronavirus pneumonia (COVID-19)
caused by the 2019 novel coronavirus (SARS-CoV-2) in China is lifting widespread …
caused by the 2019 novel coronavirus (SARS-CoV-2) in China is lifting widespread …
Iron pathways and iron chelation approaches in viral, microbial, and fungal infections
R Chhabra, A Saha, A Chamani, N Schneider, R Shah… - Pharmaceuticals, 2020 - mdpi.com
Iron is an essential element required to support the health of organisms. This element is
critical for regulating the activities of cellular enzymes including those involved in cellular …
critical for regulating the activities of cellular enzymes including those involved in cellular …
Air pollutants disrupt iron homeostasis to impact oxidant generation, biological effects, and tissue injury
AJ Ghio, JM Soukup, LA Dailey, MC Madden - Free Radical Biology and …, 2020 - Elsevier
Air pollutants cause changes in iron homeostasis through: 1) a capacity of the pollutant, or a
metabolite (s), to complex/chelate iron from pivotal sites in the cell or 2) an ability of the …
metabolite (s), to complex/chelate iron from pivotal sites in the cell or 2) an ability of the …
Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease
The low incidence of HIV-1 infection in patients with sickle cell disease (SCD) and inhibition
of HIV-1 replication in vitro under the conditions of low intracellular iron or heme treatment …
of HIV-1 replication in vitro under the conditions of low intracellular iron or heme treatment …
Protein phosphatase-1-targeted small molecules, iron chelators and curcumin analogs as HIV-1 antivirals
Background: Despite efficient suppression of HIV-1 replication, current antiviral drugs are
not able to eradicate HIV-1 infection. Permanent HIV-1 suppression or complete eradication …
not able to eradicate HIV-1 infection. Permanent HIV-1 suppression or complete eradication …
[HTML][HTML] Eltrombopag and its iron chelating properties in pediatric acute myeloid leukemia
M Argenziano, C Tortora, A Di Paola, E Pota… - Oncotarget, 2021 - ncbi.nlm.nih.gov
Pediatric acute myeloid leukemia (AML) represents 20% of total childhood leukemia
diagnoses and is characterized by poor prognosis with a long-term survival rate around the …
diagnoses and is characterized by poor prognosis with a long-term survival rate around the …
HIV-1 Transcription Inhibitor 1E7-03 Decreases Nucleophosmin Phosphorylation
Transcription activation of latent human immunodeficiency virus-1 (HIV-1) occurs due to HIV-
1 rebound, the interruption of combination antiretroviral therapy, or development of drug …
1 rebound, the interruption of combination antiretroviral therapy, or development of drug …
[HTML][HTML] Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03
We recently identified the protein phosphatase-1-targeting compound, 1E7-03 which
inhibited HIV-1 in vitro. Here, we investigated the effect of 1E7-03 on HIV-1 infection in vivo …
inhibited HIV-1 in vitro. Here, we investigated the effect of 1E7-03 on HIV-1 infection in vivo …
Recent advances in the identification of Tat-mediated transactivation inhibitors: progressing toward a functional cure of HIV
O Tabarrini, J Desantis, S Massari - Future Medicinal Chemistry, 2016 - Taylor & Francis
The current anti-HIV combination therapy does not eradicate the virus that persists mainly in
quiescent infected CD4+ T cells as a latent integrated provirus that resumes after therapy …
quiescent infected CD4+ T cells as a latent integrated provirus that resumes after therapy …
Increased expression of CDKN1A/p21 in HIV-1 controllers is correlated with upregulation of ZC3H12A/MCPIP1
SSD de Azevedo, M Ribeiro-Alves, FH Côrtes… - Retrovirology, 2020 - Springer
Background Some multifunctional cellular proteins, as the monocyte chemotactic protein-
induced protein 1 (ZC3H12A/MCPIP1) and the cyclin-dependent kinase inhibitor …
induced protein 1 (ZC3H12A/MCPIP1) and the cyclin-dependent kinase inhibitor …