Certain morphological, physiological and molecular characteristics are shared by all
neurons. However, despite these similarities, neurons constitute the most diverse cell …

The genes of the achaete-scute complex (AS-C) confer on cells the ability to become neural
precursors. Their expression is restricted to groups of cells, the proneural clusters, which …

We have isolated a cDNA clone encoding a novel helixloophdix (HLH) protein, Id. Id is
missing the basic region adjacent to the HLH domain that is essential for specific DNA …

The mouse Mash-7 gene, like its Drosophila homologs of the achaete-scute complex (AS-
C), encodes a transcription factor expressed in neural precursors. We created a null allele of …

A technique was developed for studying protein-DNA recognition that can be applied to any
purified protein, partially purified protein, or cloned gene. From oligonucleotides in which …

In Drosophila, the proneural genes of the achaete-scute complex encode transcriptional
activators that can commit cells to a neural fate. We have isolated cDNAs for two Xenopus …

The senseless (sens) gene is required for proper development of most cell types of the
embryonic and adult peripheral nervous system (PNS) of Drosophila. Sens is a nuclear …

In the Drosophila peripheral nervous system, proneural genes of the achaete-scute complex
(AX) are required for formation of the precursors of external sense organs but not of …

The helix-loop-helix (HLH) protein Id lacks the basic DNA-binding domain common to this
class of proteins. In vitro experiments suggested that Id could associate tightly with two other …

Abstract The Drosophila Achaete-Scute Complex genes encode transcriptional regulators
belonging to the basic-helix-loop-helix family which control early steps of development of the …