Histone methylases and demethylases regulating antagonistic methyl marks: changes occurring in cancer
J Taylor-Papadimitriou, JM Burchell - Cells, 2022 - mdpi.com
Epigenetic regulation of gene expression is crucial to the determination of cell fate in
development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of …
development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of …
The complex activities of the SET1/MLL complex core subunits in development and disease
H Jiang - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2020 - Elsevier
In mammalian cells, the SET1/MLL complexes are the main writers of the H3K4 methyl mark
that is associated with active gene expression. The activities of these complexes are …
that is associated with active gene expression. The activities of these complexes are …
SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1
Dysregulation of histone lysine methyltransferases and demethylases is one of the major
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …
The histone methyltransferase MLL1 directs macrophage-mediated inflammation in wound healing and is altered in a murine model of obesity and type 2 diabetes
AS Kimball, A Joshi, WF Carson IV, AE Boniakowski… - Diabetes, 2017 - Am Diabetes Assoc
Macrophages are critical for the initiation and resolution of the inflammatory phase of wound
repair. In diabetes, macrophages display a prolonged inflammatory phenotype in late wound …
repair. In diabetes, macrophages display a prolonged inflammatory phenotype in late wound …
Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin
Recent cryo-EM structures show the highly dynamic nature of the MLL1-NCP (nucleosome
core particle) interaction. Functional implication and regulation of such dynamics remain …
core particle) interaction. Functional implication and regulation of such dynamics remain …
Systematic discovery of endogenous human ribonucleoprotein complexes
RNA-binding proteins (RBPs) play essential roles in biology and are frequently associated
with human disease. Although recent studies have systematically identified individual RNA …
with human disease. Although recent studies have systematically identified individual RNA …
H3K4 methylation promotes expression of mitochondrial dynamics regulators to ensure oocyte quality in mice
N Mei, S Guo, Q Zhou, Y Zhang, X Liu, Y Yin… - Advanced …, 2023 - Wiley Online Library
Significantly decreased H3K4 methylation in oocytes from aged mice indicates the important
roles of H3K4 methylation in female reproduction. However, how H3K4 methylation …
roles of H3K4 methylation in female reproduction. However, how H3K4 methylation …
Real-Time Measurement of a Weak Interaction of a Transcription Factor Motif with a Protein Hub at Single-Molecule Precision
Transcription factors often interact with other protein cofactors, regulating gene expression.
Direct detection of these brief events using existing technologies remains challenging due to …
Direct detection of these brief events using existing technologies remains challenging due to …
Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer
X Lin, JD Chen, CY Wang, Z Cai, R Zhan, C Yang… - Genome Biology, 2023 - Springer
Background Enhancer dysregulation is one of the important features for cancer cells.
Enhancers enriched with H3K4me3 have been implicated to play important roles in cancer …
Enhancers enriched with H3K4me3 have been implicated to play important roles in cancer …
SET1/MLL family of proteins: functions beyond histone methylation
The SET1 family of enzymes are well known for their involvement in the histone 3 lysine 4
(H3K4) methylation, a conserved trait of euchromatin associated with transcriptional …
(H3K4) methylation, a conserved trait of euchromatin associated with transcriptional …