Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis,
injury of the alveolar epithelium and endothelium, hyaline membrane formation, and …

The barrier properties of endothelial cells are critical for the maintenance of water and
protein balance between the intravascular and extravascular compartments. An impairment …

Regional tissue distress caused by microcirculatory dysfunction and mitochondrial
depression underlies the condition in sepsis and shock where, despite correction of …

Our prior in vitro studies indicate that sphingosine 1-phosphate (S1P), a phospholipid
angiogenic factor, produces endothelial cell barrier enhancement through ligation of …

Background Sepsis remains a common and serious condition with significant morbidity and
mortality due to multiple organ dysfunction, especially acute lung injury (ALI) and acute …

Infiltration of activated neutrophils [polymorphonuclear leukocytes (PMN)] into the lung is an
important component of the inflammatory response in acute lung injury. The signals required …

In models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of
polymorphonuclear leukocytes (PMNs) into the lung. Since CXCR2 ligands, including …

Primary tumors secrete factors that alter the microenvironment of distant organs, rendering
those organs as fertile soil for subsequent metastatic cancer cell colonization. Although the …

Lung injury is a broad descriptor that can be applied to conditions ranging from mild
interstitial edema without cellular injury to massive and fatal destruction of the lung. This …

Acute kidney injury (AKI) occurs in about half of patients in septic shock and the mortality of
AKI with sepsis is extremely high. An effective therapeutic intervention is urgently required …