Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-
binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism …

While the phenomenon of polyadenylation has been well-studied, the dynamics of poly (A)
tail size and its impact on transcript function and cell biology are less well-appreciated. The …

Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …

Despite clear evidence that exosomal microRNAs (miRNAs) are able to modulate the
cellular microenvironment and that exosomal RNA cargo selection is deregulated in …

Certain chemical modifications confer increased stability and low immunogenicity to in vitro
transcribed mRNAs, thereby facilitating expression of therapeutically important proteins …

Exosomal miRNA transfer is a mechanism for cell–cell communication that is important in
the immune response, in the functioning of the nervous system and in cancer …

Neural stem cells show age-dependent developmental potentials, as evidenced by their
production of distinct neuron types at different developmental times. Drosophila neuroblasts …

Summary mRNAs continually change their protein partners throughout their lifetimes, yet our
understanding of mRNA-protein complex (mRNP) remodeling is limited by a lack of temporal …

Initiation is a highly regulated rate-limiting step of mRNA translation. During cap-dependent
translation, the cap-binding protein eIF4E recruits the mRNA to the ribosome. Specific …

ELAV/Hu factors are conserved RNA binding proteins (RBPs) that play diverse roles in
mRNA processing and regulation. The founding member, Drosophila Elav, was recognized …