Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

Oxidative stress and resulting lipid peroxidation is involved in various and numerous
pathological states including inflammation, atherosclerosis, neurodegenerative diseases …

Activation of de novo lipogenesis in cancer cells is increasingly recognized as a hallmark of
aggressive cancers and has been implicated in the production of membranes for rapid cell …

There is increasing awareness of the ubiquitous role of oxidative stress in
neurodegenerative disease states. A continuing challenge is to be able to distinguish …

Phospholipase A2 (PLA2) generates arachidonic acid, docosahexaenoic acid, and
lysophospholipids from neural membrane phospholipids. These metabolites have a variety …

Oxidative stress has been identified as a common mechanism for cellular damage and
dysfunction in a wide variety of disease states. Current understanding of the metabolic …

Electrophilic aldehydes, generated from oxidation of polyunsaturated fatty acyl chains under
conditions of oxidative stress, bind to proteins and polynucleotides and can lead to cell …

Lipid peroxidation products, such as 4-hydroxy-trans-2-nonenal (HNE), cause endothelial
activation, and they increase the adhesion of the endothelium to circulating leukocytes …

Lipid peroxidation yields a variety of electrophiles, which are thought to contribute to the
molecular pathogenesis of diseases involving oxidative stress, yet little is known of the …

Electrophilic products of lipid peroxidation are important contributors to the progression of
several pathological states. The prototypical α, β–unsaturated aldehyde, 4-hydroxynonenal …