Engineering organoids

M Hofer, MP Lutolf - Nature Reviews Materials, 2021 - nature.com
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Functionalizing framework nucleic‐acid‐based nanostructures for biomedical application

T Zhang, T Tian, Y Lin - Advanced Materials, 2022 - Wiley Online Library
Strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) have been
extensively explored since the first successful fabrication of tFNA by Turberfield. One‐pot …

Functionalizing DNA origami to investigate and interact with biological systems

GA Knappe, EC Wamhoff, M Bathe - Nature Reviews Materials, 2023 - nature.com
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

Programmable multispecific DNA-origami-based T-cell engagers

KF Wagenbauer, N Pham, A Gottschlich, B Kick… - Nature …, 2023 - nature.com
Multispecific antibodies have emerged as versatile therapeutic agents, and therefore,
approaches to optimize and streamline their design and assembly are needed. Here we …

Building machines with DNA molecules

H Ramezani, H Dietz - Nature Reviews Genetics, 2020 - nature.com
In nature, DNA molecules carry the hereditary information. But DNA has physical and
chemical properties that make it attractive for uses beyond heredity. In this Review, we …

Concept and development of framework nucleic acids

Z Ge, H Gu, Q Li, C Fan - Journal of the American Chemical …, 2018 - ACS Publications
The blooming field of structural DNA nanotechnology harnessing the material properties of
nucleic acids has attracted widespread interest. The exploitation of the precise and …

Cell-membrane-anchored DNA nanoplatform for programming cellular interactions

J Li, K Xun, K Pei, X Liu, X Peng, Y Du… - Journal of the …, 2019 - ACS Publications
Cell–cell interactions are mediated through compositions expressed on the membrane.
Engineering the cell surface to display functional modules with high biocompatibility, high …

Membrane sculpting by curved DNA origami scaffolds

HG Franquelim, A Khmelinskaia, JP Sobczak… - Nature …, 2018 - nature.com
Membrane sculpting and transformation is essential for many cellular functions, thus being
largely regulated by self-assembling and self-organizing protein coats. Their functionality is …

Biointerface engineering with nucleic acid materials for biosensing applications

S Shi, J Chen, X Wang, M Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Molecular recognition at the biointerface plays a critical role in sensing molecular
interactions (eg, DNA hybridization) and extracellular changes, which can directly affect the …