Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

The sympathetic and parasympathetic nervous systems regulate the activities of internal
organs, but the molecular and functional diversity of their constituent neurons and circuits …

Ghrelin, a gastric-derived acylated peptide, regulates energy homeostasis by transmitting
information about peripheral nutritional status to the brain, and is essential for protecting …

Ghrelin administration induces food intake and body weight gain. Based on these actions,
the ghrelin system was initially proposed as an antiobesity target. Subsequent studies using …

The central amygdala (CeA) consists of numerous genetically defined inhibitory neurons
that control defensive and appetitive behaviors including feeding. Transcriptomic signatures …

Much effort has been directed at studying the orexigenic actions of administered ghrelin and
the potential effects of the endogenous ghrelin system on food intake, food reward, body …

Despite the growing popular interest in sleep and diet, many gaps exist in our scientific
understanding of the interaction between circadian rhythms and metabolism. In this Review …

Objective Ghrelin is a potent orexigenic hormone, and the lateral hypothalamic area (LHA)
has been suggested as a putative target mediating ghrelin's effects on food intake. Here, we …

Agouti-related peptide (AgRP) neurons increase motivation for food, however, whether
metabolic sensing of homeostatic state in AgRP neurons potentiates motivation by …