Epidemiology, risk factors, and prevention of head and neck squamous cell carcinoma

A Barsouk, JS Aluru, P Rawla, K Saginala, A Barsouk - Medical Sciences, 2023 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is a group of malignancies, involving
the oral cavity, pharynx, hypopharynx, larynx, nasal cavity, and salivary glands, that together …

Carcinogenic human papillomavirus infection

M Schiffman, J Doorbar, N Wentzensen… - Nature reviews Disease …, 2016 - nature.com
Infections with human papillomavirus (HPV) are common and transmitted by direct contact.
Although the great majority of infections resolve within 2 years, 13 phylogenetically related …

Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis

H Mehanna, M Taberna, C Von Buchwald… - The Lancet …, 2023 - thelancet.com
Background p16 INK4a (p16) immunohistochemistry is the most widely used biomarker
assay for inferring HPV causation in oropharyngeal cancer in clinical and trial settings …

Global patterns and trends in cancers of the lip, tongue and mouth

A Miranda-Filho, F Bray - Oral oncology, 2020 - Elsevier
Objectives Global descriptions of international patterns and trends in oral cancer are
informative in providing insight into the shifting epidemiologic patterns and the potential …

Randomized trial of radiotherapy versus transoral robotic surgery for oropharyngeal squamous cell carcinoma: long-term results of the ORATOR trial

AC Nichols, J Theurer, E Prisman, N Read… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has risen
rapidly, because of an epidemic of human papillomavirus infection. The optimal …

Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial

AC Nichols, J Theurer, E Prisman, N Read… - The Lancet …, 2019 - thelancet.com
Background Transoral robotic surgery (TORS) with concurrent neck dissection has
supplanted radiotherapy in the USA as the most common treatment for oropharyngeal …

The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012

KD Shield, J Ferlay, A Jemal… - CA: a cancer journal …, 2017 - Wiley Online Library
By using data from the International Agency for Research on Cancer publication Cancer
Incidence in 5 Continents and GLOBOCAN, this report provides the first consolidated global …

Head and neck squamous cell carcinoma: update on epidemiology, diagnosis, and treatment

S Marur, AA Forastiere - Mayo Clinic Proceedings, 2016 - Elsevier
Squamous cell carcinoma arises from multiple anatomic subsites in the head and neck
region. The risk factors for development of cancers of the oral cavity, oropharynx …

Epidemiology of human papillomavirus–positive head and neck squamous cell carcinoma

ML Gillison, AK Chaturvedi, WF Anderson… - Journal of clinical …, 2015 - ascopubs.org
Human papillomavirus (HPV) is now established as the principal cause of an increase in
incidence of a subset of head and neck squamous cell cancers (HNCs) in numerous …

Oral cavity and oropharyngeal squamous cell carcinoma—an update

AC Chi, TA Day, BW Neville - CA: a cancer journal for clinicians, 2015 - Wiley Online Library
Answer questions and earn CME/CNE Oral cavity squamous cell carcinoma (OC‐SCC) is
the most common malignancy of the head and neck (excluding nonmelanoma skin cancer) …