Amyotrophic lateral sclerosis (ALS) is the most common motor neuron degenerative disease
in adults and has also been proven to be a type of conformational disease associated with …

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and prion diseases, are
directly linked to the formation and accumulation of protein aggregates in the brain. These …

Fibrils and oligomers are the aggregated protein agents of neuronal dysfunction in ALS
diseases. Whereas we now know much about fibril architecture, atomic structures of disease …

Alzheimer's disease is a neurodegenerative sickness, where the speed of personal disease
progression differs prominently due to genetic and environmental factors such as life style …

Glycosaminoglycans (GAGs) are linear polysaccharides that consist of alternating
disaccharides sequences of uronic acids and/or galactose hexamino sugars most of which …

Soluble low-molecular-weight oligomers formed during the early stage of amyloid
aggregation are considered the major toxic species in amyloidosis. The structure–function …

Amyotrophic lateral sclerosis (ALS) is the most common and severe adult-onset motoneuron
disease and has currently no effective therapy. Approximately 20% of familial ALS cases are …

The aggregation cascade of disease‐related amyloidogenic proteins, terminating in
insoluble amyloid fibrils, involves intermediate oligomeric states. The structural and …

Highlights•Inclusion of upper motor neuron health in preclinical screening is important.•Main
ALS mouse models investigating the role of CSMN are discussed.•Reporter lines of CSMN …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that is characterized by
the selective loss of motor neurons. Approximately 5% to 10% of patients with ALS have a …