New insights into activation and function of the AMPK
GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
AMPK: restoring metabolic homeostasis over space and time
E Trefts, RJ Shaw - Molecular cell, 2021 - cell.com
The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …
cellular energetic homeostasis. Recent work has been critical in establishing the …
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis
SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under
glucose starvation; the nature of the latter cell death remains unknown. Here we show that …
glucose starvation; the nature of the latter cell death remains unknown. Here we show that …
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
Ferroptosis, a form of regulated cell death that is induced by excessive lipid peroxidation, is
a key tumour suppression mechanism,,–. Glutathione peroxidase 4 (GPX4), and ferroptosis …
a key tumour suppression mechanism,,–. Glutathione peroxidase 4 (GPX4), and ferroptosis …
[HTML][HTML] SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells
The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT)
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …
[HTML][HTML] mTORC1 couples cyst (e) ine availability with GPX4 protein synthesis and ferroptosis regulation
Abstract Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid
peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 …
peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 …
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
Ferroptosis, a form of regulated cell death caused by lipid peroxidation, was recently
identified as a natural tumor suppression mechanism. Here, we show that ionizing radiation …
identified as a natural tumor suppression mechanism. Here, we show that ionizing radiation …
Energy-stress-mediated AMPK activation inhibits ferroptosis
Energy stress depletes ATP and induces cell death. Here we identify an unexpected
inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron …
inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron …
A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria
S Wu, C Mao, L Kondiparthi… - Proceedings of the …, 2022 - National Acad Sciences
Mechanisms of defense against ferroptosis (an iron-dependent form of cell death induced by
lipid peroxidation) in cellular organelles remain poorly understood, hindering our ability to …
lipid peroxidation) in cellular organelles remain poorly understood, hindering our ability to …
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer
SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival.
Here we show that this comes at a significant cost for cancer cells with high levels of …
Here we show that this comes at a significant cost for cancer cells with high levels of …