The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor
family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism …

Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges
worldwide due to their high morbidity and mortality and limitations in clinical treatment …

Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …

Ferroptosis is an iron-dependent cell death, which is characterized by iron overload and
lipid peroxidation. Ferroptosis is distinct from apoptosis, necroptosis, autophagy, and other …

Ischemic stroke is one of the main causes of high morbidity, mortality, and disability
worldwide; however, the treatment methods are limited and do not always achieve …

Activation of microglia is a common denominator and a pathophysiological hallmark of the
central nervous system (CNS) disorders. Damage or CNS disorders can trigger inflammatory …

Histone deacetylases (HDACs) are epigenetic regulators that play an important role in
determining cell fate and maintaining cellular homeostasis. However, whether and how …

Reactive oxygen species (ROS) contribute to target-cell damage in inflammatory and iron-
overload diseases. Little is known about iron transport regulation during inflammatory attack …

Iron is required in a variety of essential processes in the body. In this review, we focus on
iron transport in the brain and the role of the divalent metal transporter 1 (DMT1) vital for iron …

The loss of dopaminergic neurons of the nigrostriatal system underlies the onset of the
typical motor symptoms of Parkinson's disease (PD). Lewy bodies (LB) and Lewy neurites …