Abstract Cytochrome P450 (CYP) family 1, 2, and 3 enzymes play an essential role in the
metabolic clearance and detoxification of a myriad of structurally and chemically diverse …

Cytochrome P450 proteins (CYP450s) are present in most domains of life and play a critical
role in the metabolism of endogenous compounds and xenobiotics. The effects of exposure …

Inhibition of the lactate transporter PfFNT is a valid novel mode of action against malaria
parasites. Current pyridine-substituted pentafluoro-3-hydroxy-pent-2-en-1-ones act as …

Meloxicam is a thiazole-containing NSAID that was approved for marketing with favorable
clinical outcomes despite being structurally similar to the hepatotoxic sudoxicam …

A comprehensive method for the simultaneous characterization of xenobiotic compound
inhibition of nine major CYP enzymes in human liver microsomes was established by using …

The biotransformation of 6: 2 fluorotelomer alcohol (6: 2 FTOH) results in the production of
bioactive and persistent metabolites, including perfluorinated carboxylic acids (PFCAs) …

Abstract Cytochrome P450 2E1 (CYP2E1) metabolizes an extensive array of pollutants,
drugs, and other small molecules, often resulting in bioactivation to reactive metabolites …

Lamisil (terbinafine) is an effective, widely prescribed antifungal drug that causes rare
idiosyncratic hepatotoxicity. The proposed toxic mechanism involves a reactive metabolite …

Tyrosine kinase inhibitors (TKIs) are increasingly popular drugs used to treat more than a
dozen different diseases including some forms of cancer. Despite having fewer adverse …

Several aromatic amine compounds are urinary bladder carcinogens. Activated metabolites
and DNA adducts of polycyclic aromatic amines, such as 4-aminobiphenyl, have been …