Peptide macrocyclization has traditionally relied on lactam, lactone and disulfide bond-
forming reactions that aim at introducing conformational constraints into small peptide …

This review is dedicated to the different varieties of macrocycles synthesis bearing indole
units in their architecture by metal-catalyzed strategies. The progress of the new …

A mild and chemoselective method for the thioacylation of amines using α-keto acids and
elemental sulfur has been developed. The key to the success of this transformation is the …

Amidines are a structural surrogate for peptide bonds, yet have received considerably little
attention in peptides due to limitations in existing methods to access them. The synthetic …

Site Specific Preparation of N‐Glycosylated Peptides: Thioamide‐Directed Activation of
Aspartate - Taresh - 2022 - Angewandte Chemie - Wiley Online Library Skip to Article Content …

Macrolactonisation of peptides to generate cyclic depsipeptides is often challenging due to
the low nucleophilicity of hydroxyl groups, epimerisation, cyclodimerisation, and potential …

The AgI‐promoted reaction of thiolactams with N‐Boc amino acids yields an N‐(α‐
aminoacyl) lactam that can rearrange through an acyl transfer process. Boc‐deprotection …

A chemoselective and catalytic transamidation for peptide synthesis is described.
Transamidation under Zn catalysis is chemoselectively achieved by amino acid …

The study of macrolactonization processes has been a steady endeavor for synthetic
chemists to access macrocycles that are fundamental in the development of numerous high …

Thioamides are useful biophysical probes for the study of peptide structure and folding. The
α-C stereochemistry of thioamide amino acids, however, is easily epimerized during solid …