Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have
been associated with defects in the organization of endothelial cell junctions. Understanding …

Over the past half century molecular biology has led to great advances in our understanding
of angio-and vasculogenesis and in the treatment of malformations resulting from these …

Cerebral cavernous malformations (CCMs) are common neurovascular lesions caused by
loss-of-function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …

Cavernous vascular malformations occur with a frequency of 1: 200 and can cause recurrent
headaches, seizures and hemorrhagic stroke if located in the brain. Familial cerebral …

Cerebral cavernous malformations (CCMs) are human vascular malformations caused by
mutations in three genes of unknown function: CCM1, CCM2, and CCM3. CCM3, also …

CCM 3, a product of the cerebral cavernous malformation 3 or programmed cell death 10
gene (CCM 3/PDCD 10), is broadly expressed throughout development in both vertebrates …

Communication between neural cells and the vasculature is integral to the proper
development and later function of the central nervous system. A mechanistic understanding …

The programmed cell death 10 (PDCD10) gene was originally identified as an apoptosis-
related gene, although it is now usually known as CCM3, as the third causative gene of …

Background and Purpose—Mutations in the Programmed Cell Death 10 (PDCD10) gene
cause autosomal dominant familial cerebral cavernous malformations (CCM3). To date, little …

OBJECTIVE: Investigation of the structure of vascular malformations highlights the
pathogenic mechanisms underlying their clinical behavior. One of the vascular …