Biology of mammalian L1 retrotransposons
EM Ostertag, HH Kazazian Jr - Annual review of genetics, 2001 - annualreviews.org
▪ Abstract L1 retrotransposons comprise 17% of the human genome. Although most L1s are
inactive, some elements remain capable of retrotransposition. L1 elements have a long …
inactive, some elements remain capable of retrotransposition. L1 elements have a long …
Survey and summary transcription by RNA polymerases I and III
MR Paule, RJ White - Nucleic acids research, 2000 - academic.oup.com
The task of transcribing nuclear genes is shared between three RNA polymerases in
eukaryotes: RNA polymerase (pol) I synthesises the large rRNA, pol II synthesises mRNA …
eukaryotes: RNA polymerase (pol) I synthesises the large rRNA, pol II synthesises mRNA …
DNA targeting specificity of RNA-guided Cas9 nucleases
Abstract The Streptococcus pyogenes Cas9 (SpCas9) nuclease can be efficiently targeted to
genomic loci by means of single-guide RNAs (sgRNAs) to enable genome editing …
genomic loci by means of single-guide RNAs (sgRNAs) to enable genome editing …
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
F Zhang, RAN Fei - US Patent 8,865,406, 2014 - Google Patents
The invention provides for engineering and optimization of systems, methods, and
compositions for manipulation of sequences and/or activities of target sequences. Provided …
compositions for manipulation of sequences and/or activities of target sequences. Provided …
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
F Zhang, RAN Fei - US Patent App. 14/104,837, 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49883289&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49883289&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
F Zhang, RAN Fei - US Patent 8,895,308, 2014 - Google Patents
The invention provides for engineering and optimization of systems, methods, and
compositions for manipulation of sequences and/or activities of target sequences. Provided …
compositions for manipulation of sequences and/or activities of target sequences. Provided …
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
F Zhang, RAN Fei - US Patent 8,889,418, 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49883291&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49883291&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
CW Greider, EH Blackburn - Nature, 1989 - nature.com
The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA
sequence TTGGGG de novo in the absence of added template. The essential RNA …
sequence TTGGGG de novo in the absence of added template. The essential RNA …
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
F Zhang, N Habib - US Patent App. 14/104,900, 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49881144&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49881144&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy
F Zhang, L Cong, RAN Fei - US Patent 10,577,630, 2020 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52105121&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
52105121&utm_source= google_patent&utm_medium= platform_link&utm_campaign …