[HTML][HTML] Transsulfuration, minor player or crucial for cysteine homeostasis in cancer

HF Zhang, RIK Geltink, SJ Parker, PH Sorensen - Trends in cell biology, 2022 - cell.com
Cysteine, a thiol-containing amino acid, is crucial for the synthesis of sulfur-containing
biomolecules that control multiple essential cellular activities. Altered cysteine metabolism …

Risk factors for ischemic stroke in younger adults: a focused update

MG George - Stroke, 2020 - Am Heart Assoc
730 Stroke March 2020 migraine with aura is associated with an≈ 2-fold increase in risk of
ischemic stroke. 20, 21 However, the combination of all 3 risk factors (migraine with aura …

Cystathionine-β-synthase: molecular regulation and pharmacological inhibition

K Zuhra, F Augsburger, T Majtan, C Szabo - Biomolecules, 2020 - mdpi.com
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle …

R Sandireddy, S Sakthivel, P Gupta, J Behari… - Frontiers in cell and …, 2024 - frontiersin.org
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-
alcoholic fatty liver disease (NAFLD), is the most common liver disorder worldwide, with an …

Homocysteine: its possible emerging role in at-risk population groups

E Azzini, S Ruggeri, A Polito - International journal of molecular sciences, 2020 - mdpi.com
Increased plasma homocysteine is a risk factor for several pathological disorders. The
present review focused on the role of homocysteine (Hcy) in different population groups …

Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis

D Yuan, J Chu, H Lin, G Zhu, J Qian, Y Yu… - Frontiers in …, 2023 - frontiersin.org
Homocysteine (Hcy) is an intermediate amino acid formed during the conversion from
methionine to cysteine. When the fasting plasma Hcy level is higher than 15 μmol/L, it is …

Hyperhomocysteinemia: clinical insights

F Al Mutairi - Journal of central nervous system disease, 2020 - journals.sagepub.com
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, and intermediate metabolite
formed in metabolising methionine (Met) to cysteine (Cys); defective Met metabolism can …

Association of zoonotic protozoan parasites with microplastics in seawater and implications for human and wildlife health

E Zhang, M Kim, L Rueda, C Rochman… - Scientific reports, 2022 - nature.com
Plastics are widely recognized as a pervasive marine pollutant. Microplastics have been
garnering increasing attention due to reports documenting their ingestion by animals …

High‐dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression

DT Field, RO Cracknell, JR Eastwood… - Human …, 2022 - Wiley Online Library
Abstract Objective Vitamins B6 and B12 are involved in metabolic processes that decrease
neural excitation and increase inhibition. This double‐blind study investigated the effects of …

Pernicious anemia: the hematological presentation of a multifaceted disorder caused by cobalamin deficiency

G Esposito, L Dottori, G Pivetta, I Ligato, E Dilaghi… - Nutrients, 2022 - mdpi.com
Pernicious anemia is still a neglected disorder in many medical contexts and is
underdiagnosed in many patients. Pernicious anemia is linked to but different from …