Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis

MR Aburto, JF Cryan - Nature Reviews Gastroenterology & Hepatology, 2024 - nature.com
Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …

From flies to men: ROS and the NADPH oxidase in phagocytes

ZM Moghadam, P Henneke, J Kolter - Frontiers in cell and …, 2021 - frontiersin.org
The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient
antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which …

[HTML][HTML] Microbiota-derived lactate activates production of reactive oxygen species by the intestinal NADPH oxidase Nox and shortens Drosophila lifespan

I Iatsenko, JP Boquete, B Lemaitre - Immunity, 2018 - cell.com
Commensal microbes colonize the gut epithelia of virtually all animals and provide several
benefits to their hosts. Changes in commensal populations can lead to dysbiosis, which is …

Nutrient-Dependent Impact of Microbes on Drosophila suzukii Development

XL Bing, J Gerlach, G Loeb, N Buchon - MBio, 2018 - Am Soc Microbiol
Drosophila suzukii Matsumura is an invasive species of vinegar fly that has become a
prominent pest of berries and other soft-skinned fruits. Unlike most other Drosophila species …

Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation

X Liu, P Nagy, A Bonfini, P Houtz, XL Bing, X Yang… - Cell reports, 2022 - cell.com
Gut microbes play important roles in host physiology; however, the mechanisms underlying
their impact remain poorly characterized. Here, we demonstrate that microbes not only …

The Drosophila melanogaster Gut Microbiota Provisions Thiamine to Its Host

DR Sannino, AJ Dobson, K Edwards, ER Angert… - MBio, 2018 - Am Soc Microbiol
The microbiota of Drosophila melanogaster has a substantial impact on host physiology and
nutrition. Some effects may involve vitamin provisioning, but the relationships between …

Cellular and molecular organization of the Drosophila foregut

H Zhu, WB Ludington… - Proceedings of the …, 2024 - National Acad Sciences
The animal foregut is the first tissue to encounter ingested food, bacteria, and viruses. We
characterized the adult Drosophila foregut using transcriptomics to better understand how it …

Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in Drosophila

A Arias-Rojas, D Frahm, R Hurwitz… - Proceedings of the …, 2023 - National Acad Sciences
Resilience to short-term perturbations, like inflammation, is a fundamental feature of
microbiota, yet the underlying mechanisms of microbiota resilience are incompletely …

The role of Drosophila microbiota in gut homeostasis and immunity

G Tafesh-Edwards, I Eleftherianos - Gut Microbes, 2023 - Taylor & Francis
The gut epithelia of virtually all animals harbor complex microbial communities that play an
important role in maintaining immune and cellular homeostasis. Gut microbiota have …

Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

A Bonfini, AJ Dobson, D Duneau, J Revah, X Liu… - Elife, 2021 - elifesciences.org
The gut is the primary interface between an animal and food, but how it adapts to qualitative
dietary variation is poorly defined. We find that the Drosophila midgut plastically resizes …