A BK (Slo1) channel journey from molecule to physiology
Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology,
both in neuronal and non-neuronal cells and tissues. Through negative feedback between …
both in neuronal and non-neuronal cells and tissues. Through negative feedback between …
Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle
M Nieves-Cintrón, VA Flores-Tamez, T Le… - Cellular and Molecular …, 2021 - Springer
Diabetes affects millions of people worldwide. This devastating disease dramatically
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …
Role of potassium channels in coronary vasodilation
K+ channels in coronary arterial smooth muscle cells (CASMC) determine the resting
membrane potential (E m) and serve as targets of endogenous and therapeutic vasodilators …
membrane potential (E m) and serve as targets of endogenous and therapeutic vasodilators …
Function and regulation of large conductance Ca2+-activated K+ channel in vascular smooth muscle cells
Large conductance Ca2+-activated K+ (BKCa) channels are abundantly expressed in
vascular smooth muscle cells. Activation of BKCa channels leads to hyperpolarization of cell …
vascular smooth muscle cells. Activation of BKCa channels leads to hyperpolarization of cell …
Heart of the matter: coronary dysfunction in metabolic syndrome
Metabolic syndrome (MetS) is a collection of risk factors including obesity, dyslipidemia,
insulin resistance/impaired glucose tolerance, and/or hypertension. The incidence of obesity …
insulin resistance/impaired glucose tolerance, and/or hypertension. The incidence of obesity …
Microvascular responsiveness in obesity: implications for therapeutic intervention
Obesity has detrimental effects on the microcirculation. Functional changes in microvascular
responsiveness may increase the risk of developing cardiovascular complications in obese …
responsiveness may increase the risk of developing cardiovascular complications in obese …
Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes
X Sun, HC Lee, T Lu - Circulation Research, 2024 - Am Heart Assoc
BACKGROUND: Vascular large conductance Ca2+-activated K+ (BK) channel, composed of
the α-subunit (BK-α) and the β1-subunit (BK-β1), is a key determinant of coronary …
the α-subunit (BK-α) and the β1-subunit (BK-β1), is a key determinant of coronary …
Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes
M Nieves-Cintrón, AU Syed, OR Buonarati, RR Rigor… - Scientific reports, 2017 - nature.com
Abstract Large-conductance Ca2+-activated potassium (BKCa) channels are key
determinants of vascular smooth muscle excitability. Impaired BKCa channel function …
determinants of vascular smooth muscle excitability. Impaired BKCa channel function …
Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels
K Khavandi, RL Baylie, SA Sugden, M Ahmed… - Science …, 2016 - science.org
Activation of Ca2+-sensitive, large-conductance potassium (BK) channels in vascular
smooth muscle cells (VSMCs) by local, ryanodine receptor–mediated Ca2+ signals (Ca2+ …
smooth muscle cells (VSMCs) by local, ryanodine receptor–mediated Ca2+ signals (Ca2+ …
Role of Nrf2 signaling in the regulation of vascular BK channel β1 subunit expression and BK channel function in high-fat diet–induced diabetic mice
T Lu, X Sun, Y Li, Q Chai, XL Wang, HC Lee - Diabetes, 2017 - Am Diabetes Assoc
The large conductance Ca2+-activated K+ (BK) channel β1-subunit (BK-β1) is a key
modulator of BK channel electrophysiology and the downregulation of BK-β1 protein …
modulator of BK channel electrophysiology and the downregulation of BK-β1 protein …