Drug delivery of siRNA therapeutics: potentials and limits of nanosystems
D Reischl, A Zimmer - Nanomedicine: Nanotechnology, Biology and …, 2009 - Elsevier
Gene therapy is a promising tool for the treatment of human diseases that cannot be cured
by rational therapies. The major limitation for the use of small interfering RNA (siRNA), both …
by rational therapies. The major limitation for the use of small interfering RNA (siRNA), both …
[HTML][HTML] Non-viral nanoparticles for RNA interference: Principles of design and practical guidelines
Ribonucleic acid interference (RNAi) is an innovative treatment strategy for a myriad of
indications. Non-viral synthetic nanoparticles (NPs) have drawn extensive attention as …
indications. Non-viral synthetic nanoparticles (NPs) have drawn extensive attention as …
A multifunctional nanoplatform against multidrug resistant cancer: merging the best of targeted chemo/gene/photothermal therapy
Synergistic therapy that combines chemo‐, gene‐, or photothermal means shows great
potential for enhancing the therapeutic effects on cancers. Tumor‐targeted nanoparticles …
potential for enhancing the therapeutic effects on cancers. Tumor‐targeted nanoparticles …
[HTML][HTML] Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells
Genetic diseases are illnesses caused by abnormalities in genes or chromosomes,
including hemophilia, Huntington's disease, and cancer. They can be caused by both …
including hemophilia, Huntington's disease, and cancer. They can be caused by both …
The packaging of siRNA within the mesoporous structure of silica nanoparticles
Mesoporous silica nanoparticle (MSN) is a promising material for biomedical applications,
such as delivering drugs or biological molecules (siRNA or DNA), to the target cells or …
such as delivering drugs or biological molecules (siRNA or DNA), to the target cells or …
Overcoming the non-kinetic activity of EGFR1 using multi-functionalized mesoporous silica nanocarrier for in vitro delivery of siRNA
Triple-negative breast cancer (TNBC) does not respond to HER2-targeted and hormone-
based medicines. Epidermal growth factor receptor 1 (EGFR1) is commonly overexpressed …
based medicines. Epidermal growth factor receptor 1 (EGFR1) is commonly overexpressed …
Functionalization of silica nanoparticles for nucleic acid delivery
Silica nanoparticles (SiNPs) have been widely engineered for biomedical applications, such
as bioimaging and drug delivery, because of their high tunability, which allows them to …
as bioimaging and drug delivery, because of their high tunability, which allows them to …
A cell-penetrating helical polymer for siRNA delivery to mammalian cells
Cell-penetrating peptides (CPPs) are routinely used for intracellular delivery of a variety of
cargo, including drugs, genes, and short interfering RNA (siRNA). Most CPPs are active only …
cargo, including drugs, genes, and short interfering RNA (siRNA). Most CPPs are active only …
Adsorption and release of siRNA from porous silica
JL Steinbacher, CC Landry - Langmuir, 2014 - ACS Publications
Porous silica particles are potential transfection agents for nucleic acid-based therapies
because of their large specific surface areas and pore volumes and the ease with which they …
because of their large specific surface areas and pore volumes and the ease with which they …
Multifunctional DNA-Collagen Biomaterials: Developmental Advances and Biomedical Applications
N Pipis, BD James, JB Allen - ACS Biomaterials Science & …, 2025 - ACS Publications
The complexation of nucleic acids and collagen forms a platform biomaterial greater than
the sum of its parts. This union of biomacromolecules merges the extracellular matrix …
the sum of its parts. This union of biomacromolecules merges the extracellular matrix …