Pathology is the cornerstone of cancer care. The need for accuracy in histopathologic
diagnosis of cancer is increasing as personalized cancer therapy requires accurate …

Breast cancer is a complex disease encompassing multiple tumor entities, each
characterized by distinct morphology, behavior and clinical implications. Besides estrogen …

The role of the androgen receptor (AR) in estrogen receptor (ER)-α-positive breast cancer is
controversial, constraining implementation of AR-directed therapies. Using a diverse …

Breast cancer is a heterogeneous complex of diseases, a spectrum of many subtypes with
distinct biological features that lead to differences in response patterns to various treatment …

Breast cancer is the most common malignant disease in women worldwide. In recent
decades, earlier diagnosis and better adjuvant therapy have substantially improved patient …

Abstract Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is an essential part of the
cellular machinery that executes “programmed” or “regulated” necrosis. Here we show that …

Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of
breast cancers and its target genes dictate cell growth and endocrine response, yet genomic …

Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our
understanding of the cellular and molecular mechanisms that underlie CSC properties is …

Gene expression profiling has reshaped our understanding of breast cancer by defining and
characterizing four main intrinsic molecular subtypes: human epidermal growth factor …

Validating prognostic or predictive candidate genes in appropriately powered breast cancer
cohorts are of utmost interest. Our aim was to develop an online tool to draw survival plots …