Cancer cell dormancy is a process whereby cells enter reversible cell cycle arrest, termed
quiescence. Quiescence is essential for cancer cells to acquire additional mutations, to …

Estrogen receptor α (ER) is the major driver of∼ 75% of breast cancers, and multiple ER
targeting drugs are routinely used clinically to treat patients with ER+ breast cancer …

Circulating tumor cell (CTC) clusters mediate metastasis at a higher efficiency and are
associated with lower overall survival in breast cancer compared to single cells. Combining …

Metastasis, a multistep process during which tumor cells disseminate to secondary organs,
represents the main cause of death for cancer patients. Metastatic dormancy is a late stage …

Metastasis and relapse account for the great majority of cancer-related deaths. Most
metastatic lesions are micro metastases that have the capacity to remain in a non-dividing …

Cancer recurrence and metastasis, following successful treatment, constitutes a critical
threat in clinical oncology and are the leading causes of death amongst cancer patients …

Simple Summary Tumor recurrence still represents a major clinical challenge for cancer
patients. Cancer cells may undergo a dormant state for long times before re-emerging. Both …

Simple Summary The world of small molecules in solid tumors as cancer stem cells (CSCs),
circulating tumor cells (CTCs) and cancer-associated fibroblasts (CAFs) continues to be …

Tumor dormancy refers to a critical stage of cancer development when tumor cells are
present, but cancer does not progress. It includes both the concept of cellular dormancy …

Clinical tumor dormancy is specified as an extended latency period between removal of the
primary tumor and subsequent relapse in a cancer patient who has been clinically disease …