Targeting histone deacetylases with natural and synthetic agents: an emerging anticancer strategy
Cancer initiation and progression are the result of genetic and/or epigenetic alterations.
Acetylation-mediated histone/non-histone protein modification plays an important role in the …
Acetylation-mediated histone/non-histone protein modification plays an important role in the …
HDAC family: What are the cancer relevant targets?
O Witt, HE Deubzer, T Milde, I Oehme - Cancer letters, 2009 - Elsevier
Histone deacetylases comprise a family of 18 genes, which are grouped into classes I–IV
based on their homology to their respective yeast orthologues. Classes I, II, and IV consist of …
based on their homology to their respective yeast orthologues. Classes I, II, and IV consist of …
HDAC8: a multifaceted target for therapeutic interventions
A Chakrabarti, I Oehme, O Witt, G Oliveira… - Trends in …, 2015 - cell.com
Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic
target in various diseases, including cancer, X-linked intellectual disability, and parasitic …
target in various diseases, including cancer, X-linked intellectual disability, and parasitic …
HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics
Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two
counteracting enzyme families whose enzymatic activity controls the acetylation state of …
counteracting enzyme families whose enzymatic activity controls the acetylation state of …
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors
N Khan, M Jeffers, S Kumar, C Hackett… - Biochemical …, 2008 - portlandpress.com
The human HDAC (histone deacetylase) family, a well-validated anticancer target, plays a
key role in the control of gene expression through regulation of transcription. While HDACs …
key role in the control of gene expression through regulation of transcription. While HDACs …
Pathological role of HDAC8: cancer and beyond
JY Kim, H Cho, J Yoo, GW Kim, YH Jeon, SW Lee… - Cells, 2022 - mdpi.com
Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas
S Balasubramanian, J Ramos, W Luo, M Sirisawad… - Leukemia, 2008 - nature.com
We have developed a potent, histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051
with> 200-fold selectivity over the other HDAC isoforms. PCI-34051 induces caspase …
with> 200-fold selectivity over the other HDAC isoforms. PCI-34051 induces caspase …
Histone deacetylase 8 in neuroblastoma tumorigenesis
I Oehme, HE Deubzer, D Wegener, D Pickert… - Clinical Cancer …, 2009 - AACR
Purpose: The effects of pan–histone deacetylase (HDAC) inhibitors on cancer cells have
shown that HDACs are involved in fundamental tumor biological processes such as cell …
shown that HDACs are involved in fundamental tumor biological processes such as cell …
Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor
Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing
deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and …
deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and …
Isoform-specific histone deacetylase inhibitors: the next step?
S Balasubramanian, E Verner, JJ Buggy - Cancer letters, 2009 - Elsevier
Histone deacetylases (HDACs) have emerged as attractive drug targets, particularly for
neoplastic indications. This large family is divided into four classes, of which three consist of …
neoplastic indications. This large family is divided into four classes, of which three consist of …