Matching chelators to radiometals for radiopharmaceuticals

EW Price, C Orvig - Chemical Society Reviews, 2014 - pubs.rsc.org
Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease

TJ Wadas, EH Wong, GR Weisman… - Chemical …, 2010 - ACS Publications
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …

Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research

CJ Anderson, R Ferdani - Cancer Biotherapy and …, 2009 - liebertpub.com
Summation Copper-64 (T1/2= 12.7 hours; β+, 0.653 MeV [17.8%]; β−, 0.579 MeV [38.4%])
has decay characteristics that allow for positron emission tomography (PET) imaging and …

[HTML][HTML] Radiolabeled peptides: valuable tools for the detection and treatment of cancer

M Fani, HR Maecke, SM Okarvi - Theranostics, 2012 - ncbi.nlm.nih.gov
Human cancer cells overexpress many peptide receptors as molecular targets.
Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor …

Radiopharmaceutical chemistry for positron emission tomography

Z Li, PS Conti - Advanced drug delivery reviews, 2010 - Elsevier
Molecular imaging is an emerging technology that allows the visualization of interactions
between molecular probes and biological targets. Molecules that either direct or are subject …

A practical guide to the construction of radiometallated bioconjugates for positron emission tomography

BM Zeglis, JS Lewis - Dalton Transactions, 2011 - pubs.rsc.org
Positron emission tomography (PET) has become a vital imaging modality in the diagnosis
and treatment of disease, most notably cancer. A wide array of small molecule PET …

Development of copper based drugs, radiopharmaceuticals and medical materials

P Szymański, T Frączek, M Markowicz… - Biometals, 2012 - Springer
Copper is one of the most interesting elements for various biomedical applications. Copper
compounds show vast array of biological actions, including anti-inflammatory, anti …

The chemical scaffold of theranostic radiopharmaceuticals: radionuclide, bifunctional chelator, and pharmacokinetics modifying linker

HA Holik, FM Ibrahim, AA Elaine, BD Putra, A Achmad… - Molecules, 2022 - mdpi.com
Therapeutic radiopharmaceuticals have been researched extensively in the last decade as
a result of the growing research interest in personalized medicine to improve diagnostic …

Copper‐64‐alloyed gold nanoparticles for cancer imaging: improved radiolabel stability and diagnostic accuracy

Y Zhao, D Sultan, L Detering, S Cho, G Sun… - Angewandte …, 2014 - Wiley Online Library
Gold nanoparticles, especially positron‐emitter‐labeled gold nanostructures, have gained
steadily increasing attention in biomedical applications. Of the radionuclides used for …

Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration

E Boros, CL Ferreira, JF Cawthray… - Journal of the …, 2010 - ACS Publications
We have investigated novel bifunctional chelate alternatives to the aminocarboxylate
macrocycles NOTA (N3O3) or DOTA (N4O4) for application of radioisotopes of Ga to …