Cholangiokines: undervalued modulators in the hepatic microenvironment
The biliary epithelial cells, also known as cholangiocytes, line the intra-and extrahepatic bile
ducts, forming a barrier between intra-and extra-ductal environments. Cholangiocytes are …
ducts, forming a barrier between intra-and extra-ductal environments. Cholangiocytes are …
TNF-α/IL-1β-licensed hADSCs alleviate cholestatic liver injury and fibrosis in mice via COX-2/PGE2 pathway
X Luan, P Chen, Y Li, X Yuan, L Miao, P Zhang… - Stem Cell Research & …, 2023 - Springer
Background Adipose tissue-derived stem cell (ADSC) transplantation has been shown to be
effective for the management of severe liver disorders. Preactivation of ADSCs enhanced …
effective for the management of severe liver disorders. Preactivation of ADSCs enhanced …
WNT signaling contributes to the extrahepatic bile duct proliferative response to obstruction in mice
AN Calder, MQ Peter, JW Tobias, NHM Zaki… - JCI insight, 2024 - insight.jci.org
Biliary obstruction and cholangiocyte hyperproliferation are important features of
cholangiopathies affecting the large extrahepatic bile duct (EHBD). The mechanisms …
cholangiopathies affecting the large extrahepatic bile duct (EHBD). The mechanisms …
β-Lapachone promotes the recruitment and polarization of tumor-associated neutrophils (TANs) toward an antitumor (N1) phenotype in NQO1-positive cancers
ABSTRACT NAD (P) H: quinone oxidoreductase 1 (NQO1) is overexpressed in most solid
cancers, emerging as a promising target for tumor-selective killing. β-Lapachone (β-Lap), an …
cancers, emerging as a promising target for tumor-selective killing. β-Lapachone (β-Lap), an …
[HTML][HTML] Systemic Immune Factors and Risk of Allergic Contact Dermatitis: A Bidirectional Mendelian Randomization Study
Y Long, W Dai, K Cai, Y Xiao, A Luo, Z Lai… - International Journal of …, 2024 - mdpi.com
Skin inflammation and immune regulation have been suggested to be associated with
allergic contact dermatitis (ACD) progression, but whether the system's immune regulation is …
allergic contact dermatitis (ACD) progression, but whether the system's immune regulation is …