The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
NaV1. 7 as a pain target–from gene to pharmacology
Abstract Na V 1.7, a subtype of the voltage-gated sodium channel family that is highly
expressed in peripheral sensory neurons, remains one of the most promising targets for the …
expressed in peripheral sensory neurons, remains one of the most promising targets for the …
DRG voltage-gated sodium channel 1.7 is upregulated in paclitaxel-induced neuropathy in rats and in humans with neuropathic pain
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect
experienced by cancer patients receiving treatment with paclitaxel. The voltage-gated …
experienced by cancer patients receiving treatment with paclitaxel. The voltage-gated …
Gene variant effects across sodium channelopathies predict function and guide precision therapy
A Brunklaus, T Feng, T Brünger, E Perez-Palma… - Brain, 2022 - academic.oup.com
Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …
Nav1. 7-A1632G mutation from a family with inherited erythromelalgia: enhanced firing of dorsal root ganglia neurons evoked by thermal stimuli
Voltage-gated sodium channel Nav1. 7 is a central player in human pain. Mutations in Nav1.
7 produce several pain syndromes, including inherited erythromelalgia (IEM), a disorder in …
7 produce several pain syndromes, including inherited erythromelalgia (IEM), a disorder in …
Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability
J Huang, CG Vanoye, A Cutts… - The Journal of …, 2017 - Am Soc Clin Investig
Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range
from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on …
from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on …
Familial gain-of-function Nav1. 9 mutation in a painful channelopathy
Objective Gain-of-function mutations in Nav1. 9 have been identified in three families with
rare heritable pain disorders, and in patients with painful small-fibre neuropathy …
rare heritable pain disorders, and in patients with painful small-fibre neuropathy …
Physiology and pathophysiology of sodium channel inactivation
MR Ghovanloo, K Aimar, R Ghadiry-Tavi, A Yu… - Current topics in …, 2016 - Elsevier
Voltage-gated sodium channels are present in different tissues within the human body,
predominantly nerve, muscle, and heart. The sodium channel is composed of four similar …
predominantly nerve, muscle, and heart. The sodium channel is composed of four similar …
Sodium channels, mitochondria, and axonal degeneration in peripheral neuropathy
AK Persson, JGJ Hoeijmakers, M Estacion… - Trends in molecular …, 2016 - cell.com
Peripheral neuropathy results from damage to peripheral nerves and is often accompanied
by pain in affected limbs. Treatment represents an unmet medical need and a thorough …
by pain in affected limbs. Treatment represents an unmet medical need and a thorough …
Dexpramipexole blocks Nav1. 8 sodium channels and provides analgesia in multiple nociceptive and neuropathic pain models
Selective targeting of sodium channel subtypes Nav1. 7, Nav1. 8, and Nav1. 9, preferentially
expressed by peripheral nociceptors, represents a unique opportunity to develop analgesics …
expressed by peripheral nociceptors, represents a unique opportunity to develop analgesics …