Midbody positioning and distance between daughter nuclei enable unequivocal identification of cardiomyocyte cell division in mice
M Hesse, M Doengi, A Becker, K Kimura… - Circulation …, 2018 - Am Heart Assoc
Rationale: New strategies in the field of cardiac regeneration are directed at identifying
proliferation-inducing substances to induce regrowth of myocardium. Current screening …
proliferation-inducing substances to induce regrowth of myocardium. Current screening …
[HTML][HTML] Shared and distinct transcriptomic cell types across neocortical areas
The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …
functionally distinct areas. To investigate the diversity of cell types across the mouse …
A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality
Modern genetic approaches are powerful in providing access to diverse cell types in the
brain and facilitating the study of their function. Here, we report a large set of driver and …
brain and facilitating the study of their function. Here, we report a large set of driver and …
Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites
INTRODUCTION Vertebrate development comprises multiple complex morphogenetic
processes that shape the embryonic body plan through self-organization of pluripotent stem …
processes that shape the embryonic body plan through self-organization of pluripotent stem …
[HTML][HTML] Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions
Mammalian genomes are organized into megabase-scale topologically associated domains
(TADs). We demonstrate that disruption of TADs can rewire long-range regulatory …
(TADs). We demonstrate that disruption of TADs can rewire long-range regulatory …
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications
Abstract Internal N 6-methyladenosine (m6A) modification is widespread in messenger
RNAs (mRNAs) and is catalyzed by heterodimers of methyltransferase-like protein 3 (Mettl3) …
RNAs (mRNAs) and is catalyzed by heterodimers of methyltransferase-like protein 3 (Mettl3) …
Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation
AA Kolodziejczyk, JK Kim, JCH Tsang, T Ilicic… - Cell stem cell, 2015 - cell.com
Embryonic stem cell (ESC) culture conditions are important for maintaining long-term self-
renewal, and they influence cellular pluripotency state. Here, we report single cell RNA …
renewal, and they influence cellular pluripotency state. Here, we report single cell RNA …
[HTML][HTML] The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse
The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the
activation state of genes controlling pluripotency, lineage commitment, and cell …
activation state of genes controlling pluripotency, lineage commitment, and cell …
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Cell type–specific expression of optogenetic molecules allows temporally precise
manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse …
manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse …
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
L Madisen, TA Zwingman, SM Sunkin, SW Oh… - Nature …, 2010 - nature.com
The Cre/lox system is widely used in mice to achieve cell-type-specific gene expression.
However, a strong and universally responding system to express genes under Cre control is …
However, a strong and universally responding system to express genes under Cre control is …