Analyzing modern biomolecules: the revolution of nucleic-acid sequencing–Review

G Dorado, S Gálvez, TE Rosales, VF Vásquez… - Biomolecules, 2021 - mdpi.com
Recent developments have revolutionized the study of biomolecules. Among them are
molecular markers, amplification and sequencing of nucleic acids. The latter is classified into …

Epigenetic-mediated antimicrobial resistance: Host versus pathogen epigenetic alterations

JS Muhammad, NA Khan, SK Maciver, AM Alharbi… - Antibiotics, 2022 - mdpi.com
Since the discovery of antibiotics, humans have been benefiting from them by decreasing
the morbidity and mortality associated with bacterial infections. However, in the past few …

Genomic epidemiological analysis of Klebsiella pneumoniae from Portuguese hospitals reveals insights into circulating antimicrobial resistance

A Spadar, J Phelan, R Elias, A Modesto, C Caneiras… - Scientific Reports, 2022 - nature.com
Klebsiella pneumoniae (Kp) bacteria are an increasing threat to public health and represent
one of the most concerning pathogens involved in life-threatening infections and …

Analysis of whole-genome sequences of pathogenic Gram-positive and Gram-negative isolates from the same hospital environment to investigate common …

IS Korotetskiy, SV Shilov, T Kuznetsova… - Microorganisms, 2023 - mdpi.com
Hospital-acquired infections are a generally recognized problem for healthcare
professionals. Clinical variants of Gram-negative and Gram-positive pathogens are …

Distinct epigenetic signatures of classical and hypervirulent Klebsiella pneumoniae

D Ghosh, A Pal, S Mohapatra, S Raj, P Vivekanandan - Msphere, 2024 - Am Soc Microbiol
Emergence and spread of the hypervirulent pathotype of Klebsiella pneumoniae have
significantly increased infection rates in community as well as healthcare settings. There is …

The red thread between methylation and mutation in bacterial antibiotic resistance: How third-generation sequencing can help to unravel this relationship

S Papaleo, A Alvaro, R Nodari, S Panelli… - Frontiers in …, 2022 - frontiersin.org
DNA methylation is an important mechanism involved in bacteria limiting foreign DNA
acquisition, maintenance of mobile genetic elements, DNA mismatch repair, and gene …

Genome scale metabolic model combined with single molecule real-time sequencing to analyze Actinomycete chromosomal heterogeneity

B Han, Z Li, Z Li - Gene, 2023 - Elsevier
The rapid development of biotechnology has provided new perspectives to observe and
helped to gradually understand the significance of genetic instability in Actinobacteria. High …

DNA Methylation Patterns Differ between Free-Living Rhizobium leguminosarum RCAM1026 and Bacteroids Formed in Symbiosis with Pea (Pisum sativum L.)

AM Afonin, ES Gribchenko, EA Zorin, AS Sulima… - Microorganisms, 2021 - mdpi.com
Rhizobium leguminosarum (Rl) is a common name for several genospecies of rhizobia able
to form nitrogen-fixing nodules on the roots of pea (Pisum sativum L.) while undergoing …

Bacterial phenotype prediction based on methylation site profiles

M Nykrynova, M Bezdicek… - … IEEE Conference on …, 2023 - ieeexplore.ieee.org
Methylated site mapping in the DNA sequences plays a key role in understanding the
physiology and pathology of cells and organisms. Thanks to third-generation DNA …

Combined analysis of genome-wide DNA methylome and transcriptome reveals the first epigenetic-based antibiotic-resistance mechanism in Acinetobacter …

RN Brancaccio, V Folliero, D Di Rosa… - Discover Bacteria, 2024 - Springer
Abstract The World Health Organization (WHO) has defined carbapenem-resistant
Acinetobacter baumannii (A. baumannii) as a critical species for which new therapeutic …