Methyltransferases (MTases) play an important role in the functioning of living systems,
catalyzing the methylation reactions of DNA, RNA, proteins, and small molecules, including …

Using a TALEN-mediated gene-editing approach, we have previously described a process
for the large-scale manufacturing of" off-the-shelf" CAR T cells from third-party donor T cells …

Proteins and enzymes in the cell nucleus require physical access to their DNA target sites in
order to perform genomic tasks such as gene activation and transcription. Hence, chromatin …

The epigenetic DNA nucleobases 5-methylcytosine (5mC) and N 4-methylcytosine (4mC)
coexist in bacterial genomes and have important functions in host defence and transcription …

The first general two-step, one-pot synthetic route to 6-azopurines is presented. Microwave-
assisted nucleophilic aromatic substitution of protected 6-chloropurines with hydrazines or …

Site-specific alkylation of complex biomolecules is critical for late-stage product
diversification as well as post-synthetic labeling and manipulation of proteins and nucleic …

In this work, the preparation of new S-adenosyl-L-methionine (SAM) analogues for
sequence specific DNA labeling is evaluated. These non-natural analogues, comprising …

Methyltransferases (MTases) have become an important tool for site‐specific alkylation and
biomolecular labelling. In biocatalytic cascades with methionine adenosyltransferases …

5-Methylcytosine (5mC) and its oxidized derivatives are regulatory elements of mammalian
genomes involved in development and disease. These nucleobases do not selectively …

For a long time, DNA methyltransferases were of particular interest for basic molecular
biology research since they regulate important processes in both prokaryotes and …