Numerous pharmacologic agents used in the treatment of cancer have been linked to
pulmonary toxic side effects. Mechanisms of damage by these drugs include direct …

Having been long debated, the notion of suppressor T cells—renamed regulatory T cells—is
back on the map, but many questions remain regarding the nature of these regulatory cells …

The immunomodulatory activities of an Indian Ayurvedic medicinal preparation, ie extracts
from Ashwagandha, Withania somnifera (L.) Dunal (Solanaceae), namely WST and WS2 …

Autoimmune oophoritis that develops in A/J mice after neonatally thymectomy (NTx) was
prevented by a single intraperitoneal injection of spleen cells or thymocytes from normal …

The main points that I have put forth are that:(1) suppressor T cell activity cannot be
explained as simply being too much help;(2) feedback signals from target cells are of crucial …

Although they were used initially as non-specific immunosuppressants in transplantation,
CD3-specific monoclonal antibodies have elicited renewed interest owing to their capacity to …

Abstract Cyclophosphamide (Cytoxan; Cy) is an alkylating agent with cytotoxic and
immunosuppressive activities. The parent compound is inactive in vitro and exerts its …

Neonatal thymectomy during the critical period, 2-4 d after birth, can induce various organ-
specific autoimmune diseases including oophoritis in A/J mice. The oophoritis thus induced …

Dendritic cell-derived exosomes (DEX) are nanomeric vesicles harboring MHC/peptide
complexes capable of promoting primary T cell responses and tumor rejection in the …

Murine T lymphocytes sensitized in vitro against either allogeneic lymphocytes or syngeneic
hapten-conjugated lymphocytes do differentiate into highly effective cytotoxic T lymphocytes …