It is widely assumed that incipient protein pathology in the medial temporal lobe instigates
the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in …

Rats and mice have been demonstrated to show episodic-like memory, a prototype of
episodic memory, as defined by an integrated memory of the experience of an object or …

Neurological disorders affecting human memory present a major scientific, medical, and
societal challenge. Direct or indirect deep brain stimulation (DBS) of the entorhinal …

Deep brain stimulation (DBS) is a neurosurgical technique that regulates neuron activity by
using internal pulse generators to electrodes in specific target areas of the brain. As a blind …

In recent decades, deep brain stimulation (DBS) has been extensively studied due to its
reversibility and significantly fewer side effects. DBS is mainly a symptomatic therapy, but the …

Memory reflects the brain function in encoding, storage and retrieval of the data or
information, which is a fundamental ability for any live organism. The development of …

Background: The fornix is the primary axonal tract of the hippocampus, connecting it to
modulatory subcortical structures. This review reveals that fornix damage causes cognitive …

Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal
function, which is suggestive of neurogenesis impairments, is associated with depression …

Over the last two decades there has been an exponential rise in the number of patients
receiving deep brain stimulation (DBS) to manage debilitating neurological symptoms in …

Background Alzheimer's disease (AD) is a progressive degenerative disorder that currently
remains extremely disabling. Recent work has shown that deep brain stimulation (DBS) has …