Immunological mechanisms of vaccination
B Pulendran, R Ahmed - Nature immunology, 2011 - nature.com
Vaccines represent one of the greatest triumphs of modern medicine. Despite the common
origins of vaccinology and immunology more than 200 years ago, the two disciplines have …
origins of vaccinology and immunology more than 200 years ago, the two disciplines have …
Factors which contribute to the immunogenicity of non-replicating adenoviral vectored vaccines
L Coughlan - Frontiers in immunology, 2020 - frontiersin.org
Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-
replicating Ad vectors possess several attributes which make them attractive vaccines for …
replicating Ad vectors possess several attributes which make them attractive vaccines for …
Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species
S Colloca, E Barnes, A Folgori, V Ammendola… - Science translational …, 2012 - science.org
Replication-defective adenovirus vectors based on human serotype 5 (Ad5) induce
protective immune responses against diverse pathogens and cancer in animal models, as …
protective immune responses against diverse pathogens and cancer in animal models, as …
Recombinant adenovirus serotype 26 (Ad26) and Ad35 vaccine vectors bypass immunity to Ad5 and protect nonhuman primates against ebolavirus challenge
The use of adenoviruses (Ad) as vaccine vectors against a variety of pathogens has
demonstrated their capacity to elicit strong antibody and cell-mediated immune responses …
demonstrated their capacity to elicit strong antibody and cell-mediated immune responses …
Heterologous prime–boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory …
SY Jung, KW Kang, EY Lee, DW Seo, HL Kim, H Kim… - Vaccine, 2018 - Elsevier
Abstract The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly
pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several …
pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several …
Adenovirus membrane penetration activates the NLRP3 inflammasome
AU Barlan, TM Griffin, KA McGuire… - Journal of virology, 2011 - Am Soc Microbiol
ABSTRACT Adenovirus type 5 (Ad5) infection of macrophages results in rapid secretion of
interleukin-1β (IL-1β) and is dependent on the inflammasome components NLRP3 and ASC …
interleukin-1β (IL-1β) and is dependent on the inflammasome components NLRP3 and ASC …
TLR cross-talk confers specificity to innate immunity
Cross-talk within the innate immune pathways is highly complex and contains many
unknowns. Here, we discuss the different combinations of PAMPs, together with the …
unknowns. Here, we discuss the different combinations of PAMPs, together with the …
From co-infections to autoimmune disease via hyperactivated innate immunity: COVID-19 autoimmune coagulopathies, autoimmune myocarditis and multisystem …
R Root-Bernstein - International Journal of Molecular Sciences, 2023 - mdpi.com
Neutrophilia and the production of neutrophil extracellular traps (NETs) are two of many
measures of increased inflammation in severe COVID-19 that also accompany its …
measures of increased inflammation in severe COVID-19 that also accompany its …
Comparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T cells following human …
KM Quinn, A Da Costa, A Yamamoto… - The Journal of …, 2013 - journals.aai.org
Recombinant adenoviral vectors (rAds) are the most potent recombinant vaccines for
eliciting CD8+ T cell–mediated immunity in humans; however, prior exposure from natural …
eliciting CD8+ T cell–mediated immunity in humans; however, prior exposure from natural …
Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling
KM Quinn, DE Zak, A Costa… - The Journal of …, 2015 - Am Soc Clin Investig
Recombinant adenoviral vectors (rAds) are lead vaccine candidates for protection against a
variety of pathogens, including Ebola, HIV, tuberculosis, and malaria, due to their ability to …
variety of pathogens, including Ebola, HIV, tuberculosis, and malaria, due to their ability to …