The regulation and function of cyclin‐dependent kinase 6 (CDK6)‐and cyclin‐dependent
kinase 4 (CDK4)‐cyclin complexes are commonly altered with enhanced kinase activity …

Cancer cells bypass normal controls over mitotic cell-cycle progression to achieve a
deregulated state of proliferation. The retinoblastoma tumor suppressor protein (pRb) …

Purpose Abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor, demonstrated efficacy as
monotherapy and in combination with fulvestrant in women with hormone receptor (HR) …

Small-molecule inhibitors of the CDK4/6 cell-cycle kinases have shown clinical efficacy in
estrogen receptor (ER)-positive metastatic breast cancer, although their cytostatic effects are …

Steroid hormones exert profound effects on cell growth, development, differentiation, and
homeostasis. Their effects are mediated through specific intracellular steroid receptors that …

17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …

Most estrogen receptor α (ER)-positive breast cancers initially respond to antiestrogens, but
many eventually become estrogen-independent and recur. We identified an estrogen …

Estrogen receptor (ER) β counteracts the activity of ERα in many systems. In agreement with
this, we show in this study that induced expression of ERβ in the breast cancer cell line …

The proliferation and terminal differentiation of granulosa cells are critical for normal
follicular growth, ovulation, and luteinization. Therefore, the in situ localization and hormonal …

The central involvement of estrogen in the development of the mammary gland and in the
genesis of breast cancer has lent impetus to studies of the links between estrogen action …