Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

A healthy heart shows intrinsic electrical heterogeneities that play a significant role in
cardiac activation and repolarization. However, cardiac diseases may perturb the baseline …

Background Myocardial infarctions remain a leading cause of global deaths. Developing
novel drugs to target cardiac remodeling after myocardial injury is challenging. There is an …

The heart is a major target of thyroid hormones, with maintenance of euthyroid hormone
balance critical for proper function. In particular, chronic low thyroid function can eventually …

Background Optimal heart rate (HR) for acute hemodynamic efficiency in heart failure (HF) is
unknown. Methods Wistar-Kyoto rats were followed-up for 3 and 7 days, 1 or 2 months after …

Abstract ncRNA therapeutics can target either ncRNAs or conventional mRNA, offering both
superior pharmacokinetics and selectivity to conventional therapies and addressing new …

Ventricular arrhythmias are an important cause of mortality in the acute myocardial infarction
(MI). To elucidate the effect of the omega‐3 polyunsaturated fatty acids (PUFAs) on …

Background Myocardial infarction (MI) often results in left ventricular (LV) remodeling
followed by heart failure (HF). It is of great clinical importance to understand the molecular …

Right ventricular dysfunction (RVD) can follow primary pulmonary diseases, but the most
common cause of its development is left-sided heart failure (HF). RVD is associated with HF …

Ventricular arrhythmias are a major source of early mortality in acute myocardial infarction
(MI) and remain a major therapeutic challenge. Thus we investigated effects of ivabradine, a …