Despite the recent progress in cancer management approaches, the mortality rate of cancer
is still growing and there are lots of challenges in the clinics in terms of novel therapeutics …

Progranulin (PGRN), encoded by the GRN gene in humans, was originally isolated as a
secreted growth factor that implicates in a multitude of processes ranging from regulation of …

Regulatory noncoding RNAs (ncRNAs) are a class of RNAs transcribed by regions of the
human genome that do not encode for proteins. The three main members of this class …

Disorders of miR-484 expression are observed in cancer, different diseases or pathological
states. There is accumulating evidence that miR-484 plays an essential role in the …

There has been a progressive increase in the prevalence of obesity and its comorbidities
such as type 2 diabetes and cardiovascular diseases worldwide. Recent studies have …

Leukemias are a group of malignancies of the blood and bone marrow. Multiple types of
leukemia are known, however reliable treatments have not been developed for most …

Autoimmunity and hematological malignancies are often concomitant in patients. A causal
bidirectional relationship exists between them. Loss of immunological tolerance with …

Acute myeloid leukemia (AML) is an aggressive myeloid malignancy with poor outcomes
despite very intensive therapeutic approaches. For the majority of patients which are unfit …

Sevoflurane (SEVO) is widely applied as an anesthetic. More recently, its antitumor capacity
has been reported. However, potent mechanisms are still incompletely ascertained. In our …

Simple Summary Leukemia is a group of blood cancers that arise when abnormal or
underdeveloped blood cells accumulate in the bloodstream, bone marrow and lymphatic …