Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes

C De Graaf, D Donnelly, D Wootten, J Lau… - Pharmacological …, 2016 - Elsevier
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …

The physiology of glucagon-like peptide 1

JJ Holst - Physiological reviews, 2007 - journals.physiology.org
Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the
intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …

Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.

A Flint, A Raben, A Astrup… - The Journal of clinical …, 1998 - Am Soc Clin Investig
We examined the effect of intravenously infused glucagon-like peptide 1 (GLP-1) on
subjective appetite sensations after an energy-fixed breakfast, and on spontaneous energy …

[图书][B] Food lipids: chemistry, nutrition, and biotechnology

CC Akoh - 2017 - taylorfrancis.com
Maintaining the high standards that made the previous editions such well-respected and
widely used references, Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition …

Gastrointestinal hormones and food intake

AD Strader, SC Woods - Gastroenterology, 2005 - Elsevier
Despite dramatic fluctuations in calorie intake, animals maintain a very stable body weight.
The reason is that energy intake and expenditure are precisely matched. Long-term …

Fructose metabolism in humans–what isotopic tracer studies tell us

SZ Sun, MW Empie - Nutrition & metabolism, 2012 - Springer
Fructose consumption and its implications on public health are currently under study. This
work reviewed the metabolic fate of dietary fructose based on isotope tracer studies in …

The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity

A Flint, A Raben, AK Ersbøll, JJ Holst… - International journal of …, 2001 - nature.com
OBJECTIVE: Peripheral infusions of glucagon-like peptide-1 (GLP-1) in humans have been
shown to inhibit gastrointestinal motility and decrease hunger and energy intake. However …

Volume of food consumed affects satiety in men

BJ Rolls, VH Castellanos, JC Halford, A Kilara… - The American journal of …, 1998 - Elsevier
This study tested the hypothesis that the amount (weight or volume) of food consumed
affects the satiating potency of a food, independent of its energy content. Normal-weight …

The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases β-cell mass in diabetic mice

B Rolin, MO Larsen, CF Gotfredsen… - American Journal …, 2002 - journals.physiology.org
NN2211 is a long-acting, metabolically stable glucagon-like peptide-1 (GLP-1) derivative
designed for once daily administration in humans. NN2211 dose dependently reduced the …

Integrated upper gastrointestinal response to food intake

M Camilleri - Gastroenterology, 2006 - gastrojournal.org
Ingestion of food simultaneously activates gastrointes-tinal motility, gastric and pancreatic
secretion, and release of gastrointestinal hormones that, in turn, modulate motor, secretory …