Organic molecules as well as metal complexes may exist as several geometric isomers1
which display distinct physical properties and chemical reactivities. A molecule containing …

Due to numerous pharmaceutical and biological activities hydrazone (TC) based materials,
it was important to investigate quantum chemical studies such as Density functional theory …

Acetic acid hydrazide containing 5-methyl-2-benzoxazolinone (4) was synthesized by the
condensation of 2-(5-methyl-2-benzoxazolinone-3-yl) acetate with hydrazine hydrate …

In an attempt to design and prepare a new library of anticancer candidates, focused
thiopropargylated benzothiazole was reacted with ethyl azidoacetate and/or ethyl …

This manuscript describes a novel class of N-acylhydrazone (NAH) derivatives that act as
histone deacetylase (HDAC) 6/8 dual inhibitors and were designed from the structure of …

In the current investigation, a new class of quinazolinone N-acetohydrazides 9a-v was
designed as type II multi-kinase inhibitors. The target quinazolinones were tailored so that …

The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb)
has been driving the scientific community to urgently search for new and efficient …

In this study new 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(p-substituted benzal)
hydrazone V derivatives were synthesized as analgesic and anti-inflammatory agents. The …

The dual c-Met/vascular endothelial growth factor receptor 2 (VEGFR-2) TK inhibition is a
good strategy to overcome therapeutic resistance to small molecules VEGFR-2 inhibitors. In …

A series of isoniazid derivatives bearing a phenolic or heteroaromatic coupled frame were
obtained by mechanochemical means. Their pH stability and their structural …