There are numerous prescription drugs and non-prescription drugs that cause drug-induced
liver injury (DILI), which is the main cause of liver disease in humans around the globe. Its …

Background Liver is a vital organ responsible for metabolizing and detoxifying both
endogenous and exogenous substances in the body. However, it is susceptible to damage …

Background Liver diseases and related complications are major sources of morbidity and
mortality, which places a huge financial burden on patients and lead to nonnegligible social …

Nobiletin (Nob), a critical active flavonoid of citrus fruits, has received attention for its
superior physical functions, which have shown to improve the progression of diseases …

Cancer therapy is a growing field, and annually, a high number of research is performed to
develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer …

Amiodarone (AMD), a medicine used to treat life-threatening arrhythmias, is frequently
linked to pulmonary fibrosis (PF). Despite the involvement of NLRP3 inflammasome and …

Nobiletin (NOB) is a flavonoid derived from citrus peel that has potential as an alternative
treatment for liver disease. Liver disease is a primary health concern globally, and there is …

Purpose APAP-induced liver injury (AILI) is a common cause of acute liver failure (ALF).
Nobiletin (NOB) is a potential hepatoprotective agent for the treatment of APAP-induced liver …

Glaucoma, a common cause of blindness, is characterized by the progressive loss of retinal
ganglion cells (RGCs). Growing evidence suggests that nobiletin (NOB) is a promising …

Acetaminophen (APAP), one of the most widely used antipyretic and analgesic drugs,
principally contributes to drug-induced liver injury when taken at a high dose. APAP-induced …