The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways,
where abnormal UPS function has been observed in cancer and neurological diseases …

INTRODUCTION Cells and tissues are made up of diverse molecular building blocks,
organized with nanoscale precision over extended length scales. Newly developed …

Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

Memory persistence is critically influenced by retrieval. In rats, a single presentation of a
conditioned fear stimulus induces memory reconsolidation and fear memory persistence …

The brain changes in response to experience and altered environment. This neural plasticity
is largely mediated by morphological and functional modification of synapses, a process that …

The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in
eukaryotes. Herein, we will review advances in the understanding of the role of several …

Post-translational modification (PTM) is an essential mechanism for enhancing the
functional diversity of proteins and adjusting their signaling networks. The reversible …

Neurons are highly specialized cells whose connectivity at synapses subserves rapid
information transfer in the brain. Proper information processing, learning, and memory …

INTRODUCTION Contributing to the pathogenesis of Alzheimer's disease (AD),
oligomerized amyloid-β peptide (Aβ), neuronal hyperexcitability, and aging-associated …