Cisplatin is a chemotherapeutic drug widely used against a variety of cancers. Its clinical
utility is severely limited by its toxicity, which mainly affects, but is not limited to, the inner ear …

Parkinson's disease (PD) is one of the most common age-related neurodegenerative
diseases. This pathology causes a significant loss of dopaminergic neurons in the …

DNA damage is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS).
However, relationships between DNA damage accumulation, DNA damage response …

Kerr et al. 1 report that imatinib does not protect primordial oocytes from cisplatin-induced
apoptosis. This stands in contrast with the results of a recent report from our group in Nature …

Status epilepticus (SE) induces neuroinflammation and epileptogenesis, but the
mechanisms are not yet fully delineated. The Fyn, a non-receptor Src family tyrosine kinase …

Oxidative stress and α-synuclein aggregation both drive neurodegeneration in Parkinson's
disease, and the protein kinase c-Abl provides a potential amplifying link between these …

Poly (ADP-ribosyl) ation is a rapid and transient posttranslational protein modification mostly
catalyzed by poly (ADP-ribose) polymerase-1 (PARP1). Fundamental roles of activated …

Premature ovarian failure and infertility are adverse effects of cancer therapies. The
mechanism underlying chemotherapy-mediated depletion of the ovarian reserve remains …

Stem cells in tissues reside in and receive signals from local microenvironments called
niches. Understanding how multiple signals within niches integrate to control stem cell …

The c‐Abl tyrosine kinase is implicated in diverse cellular activities including growth factor
signaling, cell adhesion, oxidative stress, and DNA damage response. Studies in mouse …