[HTML][HTML] Current advances in lipid and polymeric antimicrobial peptide delivery systems and coatings for the prevention and treatment of bacterial infections

ME van Gent, M Ali, PH Nibbering, SN Kłodzińska - Pharmaceutics, 2021 - mdpi.com
Bacterial infections constitute a threat to public health as antibiotics are becoming less
effective due to the emergence of antimicrobial resistant strains and biofilm and persister …

[HTML][HTML] Targeted therapeutic strategies in the battle against pathogenic bacteria

B Yang, D Fang, Q Lv, Z Wang, Y Liu - Frontiers in pharmacology, 2021 - frontiersin.org
The emergence and rapid spread of antibiotic resistance in pathogenic bacteria constitute a
global threat for public health. Despite ongoing efforts to confront this crisis, the pace of …

Antimicrobial activity of synthetic antimicrobial peptides loaded in poly-Ɛ-caprolactone nanoparticles against mycobacteria and their functional synergy with rifampicin

A Sharma, A Gaur, V Kumar, N Sharma, SA Patil… - International Journal of …, 2021 - Elsevier
Tuberculosis (TB) treatment has become a challenge because of the natural presence of
multilayered cell wall rich in lipids which restrict antibiotic permeability within the bacteria …

Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics

MJA Hein, M Kvansakul, FT Lay… - Biochemical Society …, 2022 - portlandpress.com
Defensins are a class of host defence peptides (HDPs) that often harbour antimicrobial and
anticancer activities, making them attractive candidates as novel therapeutics. In comparison …

[HTML][HTML] Functional insights to the development of bioactive material for combating bacterial infections

D Fan, X Liu, Y Ren, S Bai, Y Li, Z Luo… - … in Bioengineering and …, 2023 - frontiersin.org
The emergence of antibiotic-resistant “superbugs” poses a serious threat to human health.
Nanomaterials and cationic polymers have shown unprecedented advantages as effective …

Bacterial aggregation triggered by fibril forming tryptophan-rich sequences: effects of peptide side chain and membrane phospholipids

M Bagheri, H Nikolenko, S Arasteh… - … applied materials & …, 2020 - ACS Publications
The influence of side chain residue and phospholipid characteristics of the cytoplasmic
membrane upon the fibrillation and bacterial aggregation of arginine (Arg) and tryptophan …

[HTML][HTML] Assessing the Efficacy of PLGA-Loaded Antimicrobial Peptide OH-CATH30 Microspheres for the Treatment of Bacterial Keratitis: A Promising Approach

X Jiao, X Dong, H Shan, Z Qin - Biomolecules, 2023 - mdpi.com
Bacterial keratitis in animals presents challenges due to ocular structural barriers, hindering
effective drug delivery. In this study, we used biocompatible and biodegradable poly (lactic …

Alginate microspheres elicit innate M1-inflammatory response in macrophages leading to bacillary killing

K Vaghasiya, A Eram, A Sharma, E Ray, S Adlakha… - AAPS …, 2019 - Springer
Particulate drug delivery systems (PDDS) have been broadly explored as platforms for
delivery of drugs, enzymes, cells, and vaccines for pharmaceutical applications. Studies …

Formulation of host-targeted therapeutics against bacterial infections

DM Varma, MSH Zahid, EM Bachelder… - Translational Research, 2020 - Elsevier
The global burden of bacterial infections is rising due to increasing resistance to the majority
of first-line antibiotics, rendering these drugs ineffective against several clinically important …

Aurothioglucose encapsulated nanoparticles fostered neuroprotection in streptozotocin-induced Alzheimer's disease

SK Kushawaha, MS Ashawat, D Soni, P Kumar, A Baldi - Brain Research, 2024 - Elsevier
Alzherimer's disease (AD) is an age-dependent ubiquitous ailment worldwide with limited
therapies that only alleviate the symptoms of AD but do not cure them entirely because of the …