Hydatidiform moles: genetic basis and precision diagnosis

P Hui, N Buza, KM Murphy… - Annual Review of …, 2017 - annualreviews.org
Hydatidiform moles are intriguing pathologic entities representing abnormal placental villous
tissue with unique genetic profiles and a wide spectrum of morphologic features, which …

Genetics and epigenetics of recurrent hydatidiform moles: basic science and genetic counselling

NMP Nguyen, R Slim - Current obstetrics and gynecology reports, 2014 - Springer
Gestational trophoblastic disease (GTD) is a group of conditions that originate from the
abnormal hyperproliferation of trophoblastic cells, which derive from the trophectoderm, the …

Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy

NJ Sebire, RA Fisher, M Foskett, H Rees… - BJOG: an international …, 2003 - Elsevier
OBJECTIVE: To determine pregnancy outcome, including the rate of repeat molar
pregnancy, following histologically confirmed complete or partial hydatidiform mole …

Biallelic NLRP7 variants in patients with recurrent hydatidiform mole: A review and expert consensus

R Slim, R Fisher, F Milhavet, R Hemida… - Human …, 2022 - Wiley Online Library
Hydatidiform mole (HM) is an abnormal human pregnancy characterized by excessive
growth of placental trophoblasts and abnormal early embryonic development. Following a …

Gestational trophoblastic diseases-clinical guidelines for diagnosis, treatment, follow-up, and counselling

I Niemann, LO Vejerslev, L Frøding, J Blaakær… - Danish Medical …, 2015 - pure.au.dk
Hydatidiform mole is treated with surgical uterine evacuation with suction and blunt
curettage (D). Medical uterine evacuation should not be used (C). On clinical suspicion of …

NLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges

R Slim, EP Wallace - Frontiers in immunology, 2013 - frontiersin.org
NOD-like receptor proteins (NLRPs) are emerging key players in several inflammatory
pathways in Mammals. The first identified gene coding for a protein from this family is Nlrp5 …

[HTML][HTML] A novel mutation in NLRP7 related to recurrent hydatidiform mole and reproductive failure

J Fallahi, V Razban, M Momtahan… - … Journal of Fertility & …, 2019 - ncbi.nlm.nih.gov
Background Hydatidiform mole (HM) is an abnormal human pregnancy with excessive
trophoblastic proliferation and abnormal embryonic development, dividing into two complete …

Psychosocial and reproductive outcomes of gestational trophoblastic diseases

E Garner, DP Goldstein, RS Berkowitz… - Best practice & research …, 2003 - Elsevier
Current therapy for molar pregnancy and gestational trophoblastic neoplasias (GTNs) has
resulted in high cure rates with preservation of fertility, even in the setting of chemotherapy …

Subsequent pregnancy outcome in patients with spontaneous resolution of HCG after evacuation of hydatidiform mole: comparison between complete and partial …

H Matsui, Y Iitsuka, K Suzuka, K Seki… - Human …, 2001 - academic.oup.com
This study compared subsequent pregnancy outcome in patients with complete and partial
hydatidiform moles. Among 1052 patients with molar pregnancy (complete mole, 801; partial …

Comprehensive genotype–phenotype correlations between NLRP7 mutations and the balance between embryonic tissue differentiation and trophoblastic proliferation

NMP Nguyen, L Zhang, R Reddy, C Déry… - Journal of Medical …, 2014 - jmg.bmj.com
Background Hydatidiform mole (HM) is a human pregnancy with excessive trophoblastic
proliferation and abnormal embryonic development that may be sporadic or recurrent. In the …