The von Hippel-Lindau (VHL) Cullin RING E3 ligase is an essential enzyme in the ubiquitin-
proteasome system that recruits substrates such as the hypoxia inducible factor for …

The electronic properties and relatively small size of fluorine endow it with considerable
versatility as a bioisostere and it has found application as a substitute for lone pairs of …

The current scale of plastics production and the attendant waste disposal issues represent
an underexplored opportunity for chemically recyclable polymers. Typical recyclable …

In recent years, intramolecular noncovalent interaction has become an important means to
modulate the optoelectronic performances of organic/polymeric semiconductors. However, it …

Favorable molecular interactions between group 16 elements have been implicated in
catalysis, biological processes, and materials and medicinal chemistry. Such interactions …

Conspectus The carbonyl group holds a prominent position in chemistry and biology not
only because it allows diverse transformations but also because it supports key …

Electron deficient, bivalent sulfur atoms have two areas of positive electrostatic potential, a
consequence of the low-lying σ* orbitals of the C–S bond that are available for interaction …

Bioorthogonal chemistries enable researchers to interrogate biomolecules in living systems.
These reactions are highly selective and biocompatible, and can be performed in many …

Proteins and their assemblies are fundamental for living cells to function. Their complex
three-dimensional architecture and its stability are attributed to the combined effect of …

A complete inventory of the forces governing protein folding is critical for productive protein
modeling, including structure prediction and de novo design, as well as understanding …