The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

Our understanding of development and function of natural killer (NK) cells has progressed
significantly in recent years. However, exactly how uterine NK (uNK) cells develop and …

Decidual natural killer (dNK) cells are the tissue-resident and major subpopulation of NK
cells at the maternal-fetal interface. It has been demonstrated that dNK cells play pivotal …

Allogeneic individuals co‐exist during pregnancy in eutherian mammals. Maternal and fetal
cells intermingle at the site of placental attachment in the uterus, where the arteries are …

The presence of granulated lymphocytes in the human uterine mucosa, known as decidua
during pregnancy, or endometrium otherwise, was first noted in the nineteenth century, but it …

BACKGROUND Although the immune system intuitively must have an important role in
embryo implantation and in the achievement of a pregnancy, the molecular details have for …

Killer cell immunoglobulin‐like receptors (KIR s) on natural killer (NK) cells are crucially
involved in the control of cancer development and virus infection by probing cells for proper …

Human leukocyte antigen G (HLA-G) mediates maternal-fetal immune tolerance. It is also
considered an immune checkpoint in cancer since it may mediate immune evasion and thus …

HLA-G is known to modulate the immune system activity in tissues where physiological
immune-tolerance is necessary (ie, maternal-fetal interface, thymus, and cornea). However …

The surveillance of target cells by natural killer (NK) cells utilizes an ensemble of inhibitory
and activating receptors, many of which interact with major histocompatibility complex …