Epilepsy is a common neurological disorder, affecting patients of all ages, reducing the
quality of life, and associated with several comorbidities. Sleep impairment is a frequent …

The correlation between sleep and epilepsy has been argued over the past decades among
scientists. Although the similarities and contrasts between sleep and epilepsy had been …

Lateral hypothalamic (LH) hypocretin/orexin neurons (HONs) control brain-wide electrical
excitation. Abnormally high excitation produces epileptic seizures, which affect millions of …

Epilepsy is characterized by the occurrence of repetitive seizures and can greatly affect a
patient's cognition, particularly in terms of learning and memory. Orexin-A is an excitatory …

Interest in orexin receptor antagonism as a novel mechanism of action against seizures and
epilepsy has increased in recent years. Loss of orexinergic activity is associated with rapid …

Background Paroxysmal sleep disorders in children are important from both
pathophysiological and clinical point of view. Correct diagnosis is crucial for further …

Introduction Orexin is a neuropeptide neurotransmitter that regulates the sleep/wake cycle
produced by the lateral hypothalamus neurons. Recent studies have shown the involvement …

Orexins/hypocretins and their receptors (OXRs) are ubiquitously distributed throughout the
nervous system and peripheral tissues. Recently, various reports have indicated that orexins …

Convulsive seizures are due to abnormal synchronous and repetitive neuronal discharges
in the central nervous system (CNS). Finding new therapeutics to overcome the side effects …

Orexin is a neurotransmitter that mainly regulates sleep/wake cycle. In addition to its sleep
cycle regulatory role, it is involved in regulation of attention, energy homeostasis …